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Seminal discovery in vascular development celebrated

SeniorPortrait200

Senior Centenary Tribute

This year marks the centenary of the publication by H. D. Senior of two monumentally enduring papers on the transitioning and adult arterial anatomy of the human lower limb [1, 2]. Later anatomy texts (Figure One) [3] have illustrated the stages in the development of the arteries of the limb from an early Axis Artery (AA) to the habitual more complex arterial anatomy of the mature pattern, which is perfected via a series of overlapping primitive arteries. The primitive vessels may incompletely regress to contribute to the later adult composite vessels by the end of the end of the seventh embryonic week. Gray's textbook anatomy contains a single illustration of the regressed portion of the axial artery melded into the mature pattern (Figure Two) [4].

As the limbs grow out during a phase of rapid crown-rump (CR) growth, the embryo triples in length from 10mm to 30mm over a 2 ½ week period. The AA forms in situ from mesodermal tissues [5], while the transitional arteries are composed of angioblasts which migrate into the limb from extrinsic sites via a process termed angiogenesis [6]

The transitioning of the primitive arteries has been adduced to present a 'risk factor' for limb teratogenesis due to weakness of the muscular coating of the emerging vessels [7]. Similarly, Thalidomide has infamously been proven to act through injury to such forming embryonic arteries [8].

A majority of human lower limb malformations have been endorsed pathologically as variable expressions of postspecification/patterning errors of limb development [9]. A new clinical syndrome [10] of congenital long bone deficiencies of the lower limb, involving the proximal femur, fibula and midline metatarsals, have been aggregated into a single entity based on a commonality of those three sites as transitional areas of angiogenesis. Senior's works provided the road map for understanding the relationship between the transitioning arteries and the congenital long bone deficiencies. A century later, Senior's efforts endure as his legacy.

David Hootnick, MD  

 

FigureSenior1

Figure One

FigureSenior2

Figure Two

 

  1. Senior H (1919) The development of the arteries of the human lower extremity. Am J Anat 25:54-95
  2. Senior HD (1919) An Interpretation of the Recorded Arterial Anomalies of the Human Leg and Foot. J Anat 53:130-171
  3. Patten B (1946) Figure 401: Development of arteries of extremities. In: Anonymous Human Embryology, 1st edn. The Blakiston     Company, Philadelphia, pp 635.
  4. Senior H (1985) Development of the arteries. In: Clemente CD (ed) Gray’s Anatomy, 13th American ed. edn. Williams & Wilkins, Baltimore, MD, pp 658.
  5. Risau W (1997) Mechanisms of angiogenesis. Nature 386:671-674
  6. Ambler CA, Nowicki JL, Burke AC, Bautch VL (2001) Assembly of trunk and limb blood vessels involves extensive migration and vasculogenesis of somite-derived angioblasts. Dev Biol 234:352-364
  7. Vargesson N, Hootnick DR (2017) Arterial dysgenesis and limb defects: Clinical and experimental examples. Reprod Toxicol 70:21-29
  8. Therapontos C, Erskine L, Gardner ER, Figg WD, Vargesson N (2009) Thalidomide induces limb defects by preventing angiogenic outgrowth during early limb formation. Proc Natl Acad Sci U S A 106:8573-8578
  9. Packard DS,Jr, Levinsohn EM, Hootnick DR (1993) Most human lower limb malformations appear to result from postspecification insults. Prog Clin Biol Res 383A:417-426
  10. Hootnick DR, Vargesson N (2018) The syndrome of proximal femur, fibula, and midline metatarsal long bone deficiencies. Birth Defects Res 110:1188-1193

Child Care Grants

Meeting Child Care Grants


Applying for a Grant


Small grants up to $400 per family are available for NAVBO meeting attendees who are bringing young children to a meeting or who incur extra expenses for childcare during the meeting. Grants are available for Vascular Biology 2019.


Apply Online


Applications are now open. To apply, complete the online childcare grant application by the deadline below.


Vascular Biology Child Care Grant
Deadline: September 10, 2019


Allowable Expenses:

 

  • Child care expenses at the site of the meeting*
  • Extra child/dependent care expenses at home incurred because the primary caregiver was attending the meeting (such as overtime at a child care center, cost of a sitter, etc.)
  • Expenses incurred in bringing a caregiver and/or dependent

Receipts will be required for reimbursement.

*NAVBO does not provide or recommend child care providers and does not assume responsibility or liability for child care services of any sort. It is the responsibility of the parent(s) or guardian(s) to thoroughly investigate all child care providers.


Unallowable Expenses:

 

  • Regular home-based child/dependent care expenses
  • Travel or other expenses related to the attendee’s participation in the meeting (including meeting registration, meals, travel to the meeting, or other expenses the attendee would already be incurring by attending the meeting)
  • Food
  • Tickets to local museums, amusement parks, etc.

 

Selecting Grants


If the number of requests for grants exceeds the funding, preference will be given to applicants in the early stages of their careers.


Application Misrepresentation


NAVBO reserves the right to deny funds to applicants who misrepresent their funding needs.


Changes in Circumstances


If the need for your grant changes between when you applied and the date of the Meeting, you must notify NAVBO to explain. You will be notified if your need is still eligible for funding.

Vascular Biology 2019 Program

Sunday, October 27

 

2:00-6:00pm

Pre-Conference Meeting for Trainees

Chairs: Arif Yurdagul, Columbia University and Xiaolei Liu, Northwestern University
Featured Speakers:

Martin Schwartz, Yale University
Going with the flow in vascular cell biology
Jan Kitajewski, University of Illinois at Chicago
Fate Determination - branching out, maturing, going with the flow

Panel Discussion: "Taking the Next Steps in Your Career"
with Zhiyu Dai, University of Arizona, Monica Lee, University of Illinois at Chicago and
Sathish Srinivasan, Oklahoma Medical Research Foundation

Trainee speakers to be selected from abstract submissions

Joint Session

7:15-8:45pm

Opening Session

Presentation of Travel Awards

Keynote Lecture: Hal Dietz, Johns Hopkins Medical Center
Leveraging nature's success: lessons from modifiers of cardiovascular disease

Earl P. Benditt Award Lecture:  William C. Sessa, Yale School of Medicine
Integration of endothelial function and lipid metabolism

Monday, October 28

 

 

Concurrent Sessions
8:30-10:00am

Origins of the Vasculature

Christiana Ruhrberg, University College London
A novel source of endothelial cells for organ vascularization

Didier Stainier, Max Planck Inst for Heart & Lung Res
Lymphatic development in zebrafish and mouse

Intersection of Tissue Engineering and Computational Modeling

Alison Marsden, Stanford University
Computer models that direct new surgical approaches and predict pediatric vascular disease outcomes

Stephen Chan, University of Pittsburgh
Leveraging systems biology to decipher ECM-driven pulmonary vascular metabolic reprogramming

Concurrent Sessions

10:30am-12:15pm

Signaling in the Vasculature

Mark Kahn, University of Pennsylvania
Mechanisms of lymphatic vessel repair and regrowth

Luisa Iruela-Arispe, UCLA
How do vessels grow after tubulogenesis?

Disease modeling with Biomedical Engineering

Jay Humphrey, Yale University
From mouse to computational models of central artery diseases

Kurt Stenmark, University of Colorado
Tissue-informed engineering strategies for modeling human pulmonary diseases 

 
12:15-1:30pm

Networking Lunch – Meet the Professors

Concurrent Sessions

1:45-4:00pm

Blood Vessel Morphogenesis

Co-sponsored by the Microcirculatory Society

Victoria Bautch, University North Carolina Chapel Hill
How blood vessels control their own destiny

Ondine Cleaver, UT Southwestern Medical Center
How vessel tubes are made and maintained

Brant Weinstein, NICHD/NIH
Vessel morphogenesis in the zebrafish brain

Vascular Calcification and Valve Development

Elena Aikawa, Brigham & Women’s Hospital/HMS
3D modeling to engineer and cure cardiovascular calcification

Raul Guzman, Beth Israel Deaconess Medical Center
Role of MMPs in arterial calcification

 

 

 
4:30-5:30pm

Nano-Talks: Late breaking submissions (ten 5-minute talks)

Evening

Poster Session 1

Tuesday, October 29


Concurrent Sessions

8:30-10:00am

Lymphangiogenesis

Co-sponsored by the Microcirculatory Society

Taija Mäkinen, Uppsala University
Vascular-bed specific mechanisms of lymphatic development and disease

Sathish Srinivasan, Oklahoma Med Research Fndn
Mechanisms of Wnt/beta-catenin signaling in lymphatic vascular development

Extracellular Matrix and Disease

Sarah Heilshorn Stanford University
Extracellular matrix and 3-D printing: A combined approach to vascular regeneration

Suneel Apte, Lerner Research Institute, Cleveland Clinic
Extracellular matrix and its proteolytic turnover in vascular wall disorders

Concurrent Sessions

10:30am-12:15pm

Artery-Vein Differentiation

Kristy Red-Horse, Stanford University
Development and regeneration of coronary arteries

Karen Hirschi, Yale School of Medicine
Regulation of endothelial cell specification

 

MCS Session: Microphysiological Models of the Microcirculation

Roger Kamm, Massachusetts Institute of Technology
Transport properties of a model blood-brain barrier

Jenny Munson, Virginia Tech
Therapeutic response models at tumor-lymphatic interface

Concurrent Sessions

1:45-3:45pm

Therapeutic Potential of Induced Pluripotent Stem Cell-derived ECs
Organized by Juan Melero-Martin

Joseph Wu, Stanford University
Stem cells & genomics- precision cardiovascular medicine

Juan Melero-Martin, Boston Children’s Hospital
Competent endothelial cells derived from human iPS cells with high efficiency

Mingxia Gu, Stanford University
iPSC derived vascular cells in disease modeling: Toward therapeutic discovery and precision medicine 

Bioengineering Vascularized Tissues for Regenerative Medicine
Organized by: Ngan Huang

Co-sponsored by the Microcirculatory Society

Sharon Gerecht, Johns Hopkins University
iPSC-derived vascular networks for therapeutics

Christopher S. Chen, Boston University
Engineering of vascular networks that induce therapeutic angiogenesis in ischemia

Ngan Huang, Stanford University
Induction of angiogenesis and endothelial fate differentiation using patterned nanofibrillar scaffolds

4:15-6:15pm

Bootcamp:  Tissue Clarity and LightSheet Imaging

Evening

Poster Session 2

Wednesday, October 30

Concurrent Sessions

8:30-10:00am

Mural Cell Origins and Functions

Yosuke Mukoyama, NHLBI/NIH
Neuro-vascular morphogenesis

Ralf H. Adams, Max-Planck Institute for Molecular Biomedicine
YAP1 and TAZ negatively control bone angiogenesis by limiting hypoxia-inducible factor signalling in endothelial cells

Mechanotransduction

Co-sponsored by the Microcirculatory Society

Wayne Orr, LSU Health Sciences Center
A novel mechanism of flow-induced ER stress

Martin Schwartz, Yale School of Medicine
Molecular mechanisms of endothelial fluid shear stress sensing and signaling

Concurrent Sessions

10:30am-12:00pm

MCS Session: Integrative Function in the Microcirculation

Shayn Peirce-Cottler, University of Virginia
Pericytes as integrators of tissue health status and microvascular function

Steve Segal, University of Missouri
Microvascular remodeling in skeletal muscle regeneration

Courtney Griffin, Oklahoma Med Research Foundation
Developmental crosstalk between macrophages and microvessels

Genetic Mechanisms Underlying Vascular Disease

Diana Milewicz, UTexas Health Sciences Center at Houston
Genes linked to thoracic aortic aneurysms implicate mechanotransduction as a primary disease driver

Beth Kozel, NHLBI/NIH
Elastic fiber disease - modifiers and mechanism

Joint Session

2:00-3:15pm

NAVBO Folkman and Springer Award Presentation and Lectures

Judah Folkman Award in Vascular Biology Lecture:  Anne Eichmann, Yale School of Medicine
Guidance of vascular barrier formation

Springer Award Recipient to be announced

Joint Session

3:30-5:45pm

Vascular Therapeutics:Vascular Transcriptomics - Discovery and Therapeutic Opportunities

Session Chairs: Jan Kitajewski, University of Illinois at Chicago and Nicholas Gale, Regeneron

Henar Cuervo, University of Illinois at Chicago
Transcriptomes and vascular pericytes

Christer Betsholtz, Karolinska Institute/Uppsala University
Vascular single-cell transcriptomics

Amber Stratman, Washington University in St. Louis
Transcriptomic analysis of vascular smooth muscle cells in zebrafish

Qi Zhao, Regeneron
Transcriptomic analysis of tumor vasculature

7:15-10:00pm

Anniversary Celebration!!

 Thursday, October 31

Joint Session

8:30am-12:30pm

Emerging Technologies and Imaging

Co-programmed by the Microcirculatory Society

Nathan Lawson, University of Massachusetts
Investigating cardiovascular cell heterogeneity in the zebrafish, one cell at a time

Rui Benedito, Centro Nacional de Investigaciones Cardiovasculares
Using multispectral genetic mosaics to enlighten endothelial heterogeneity during angiogenesis

Todd McDevitt, University of California, San Francisco
Engineering cardiac microtissues to interrogate mechanisms of heterotypic interactions

Song Hu, University of Virginia
Listening with light: photoacoustic microscopy of the microcirculation in vivo

Several abstracts will be added to this session

Then and Now

Help NAVBO celebrate its 25th Anniversary by celebrating you, the NAVBO member.  Share with other members how you have changed, how your science has changed, or how your methods have changed.  Let's take a look at how the field of vascular biology has evolved over the past 25 years.  Send your photos, stories and videos to This email address is being protected from spambots. You need JavaScript enabled to view it..

Then

Now

Rosemary Akhurst

R Akhurst Dec1994

“Reader” at Glasgow University Dept Medical Genetics at the time (Reader is equivalent to a senior associate professor)

 
RosemaryAkhurst

Rosemary is currently a Professor In Residence, Helen Diller Family
Comprehensive Cancer Center at UCSF

Michelle Bendeck

MichelleBendeck Then

In 1994, Michelle Bendeck was a postdoc at the
University of Washington in Seattle.

 

MichelleBendeckNow

Today, Michelle is the NAVBO Past President!
and a Professor at the University of Toronto

Elisa Boscolo

BoscoloThen

Elisa Boscolo, in Venice Italy, she was admiring her birthday cake - can you guess her age in this picture??

BoscoloInBetweenBoscoloNow

 

 

 

 

 

Elisa at the 2012 IVBM in       Elisa is now Assistant Professor Germany (she was a post-      at Cincinnati Children’s
doc in J. Bischoff's lab)              Hospital and yes, she still likes
                                                                birthday cake, but not the
                                                                 candles!!
                                                                

Ondine Cleaver

OndineThen

Ondine was a second year graduate student in Paul Krieg's lab at the University of Texas-Austin

 

OndineNow

Ondine is now a Professor at UT Southwestern
and is currently NAVBO's President!

Michael Dellinger

DellingerThen

Michael was a skater in 8th grade at
Desert Horizon Elementary School in Phoenix

 

DellingerNow

Now Mike enjoys fishing and is an 
Assistant Professor at UT Southwestern.

Zorina Galis

Galis Then

Research Fellow, Vascular Medicine
and a NAVBO Founding Member

 

Galis Now

Chief of Vascular Biology and Hypertension, NHLBI
and NAVBO Councilor

 Jan Kitajewski

Kitajewski Before NAVBO

Assistant Professor of Pathology at
Columbia University in New York, NY

 

KitajewskiNow200

Head of the Department of Physiology
at University of Illinois Chicago, IL

Bill Muller

Bill Muller then

"Here I am in my carefree days
when NAVBO was young and so was I."

 Bill Muller now20025 years of vascular biology including serving as NAVBO President, long stints on the Council as Secretary/Treasurer, and even Chair of the Program Committee (back when there was such a thing), has taken a toll on me.  Those of you who have only met me recently might not think so, but I’m the one on the left in the “Then” picture.  

Wayne Orr

NAVBO Then and Now Orr

Wayne was in high school and on stage in Oklahoma!  
(The musical, not the state!) in 1994

 

OrrBallot

Wayne is currently the Director,
Center for Cardiovascular Diseases and Sciences; 
Professor and Director, Division of Research in the
Department of Pathology and Translational Pathobiology at LSU Health, Shreveport and on the NAVBO council

Kristy Red-Horse

RedHorseThen

Kristy was graduating from Benton High School in Akansas. 
(I'm sure she had honors in science!)

 RedHorseNow200

Kristy is now an Associate Professor at Stanford. 
Here she is in the Rodin Garden on Stanford's campus

Linda Shapiro

ShapiroThen

Linda in 1994 with her beautiful children.  She was an Assistant Professor at St. Jude in Memphis, Department of Hematology.

 

ShapiroNow

Today, Linda is the Director of the Center for Vascular Biology at UConn
and was recently elected to the NAVBO Council.  
Here she is with family at her daughter's wedding.

Cynthia St. Hilaire

CindyThen200

In 1994, Cindy was aspiring for a better summer job when she finally get her driver's license!

 St.Hilaire2

Cindy is now an Assistant Professor of Medicine at the University of Pittsburgh,
 Division of Cardiology and Faculty Member,
Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute
Cindy just joined the NAVBO Council!

 Bernadette Englert

BME Then200

Bernadette married Robert Skelton in May, 1994.  She had already begun her work with NAVBO as their Administrator.

 

BME headshot

Bernadette at the IVBM 2016
(it's three years ago, but she hasn't changed that much)

   

 

Mentorship Program

New Mentorship Program at Vasculata 2019

This is a new component for Vasculata.  We hope to enrich the experience and continue attendees' education and growth in the vascular biology community.  

Potential Mentors:

For the past few months, the NAVBO Membership Committee has been considering the best approach for setting up a mentoring program within NAVBO. We find many move onto other fields after their graduate studies or postdoctoral training and believe this type of program may inspire them to remain in vascular biology.  In collaboration with Dr. Ramani Ramchandran, a key organizer of this year’s Vasculata and his organizing committee members, we have developed a program that will be exclusively for those attending Vasculata.

We are seeking volunteers to mentor the Vasculata attendees. These attendees range from undergraduate students to postdoctoral fellows, with the highest percentage being graduate students. This would be an online mentoring program, mentors would not need to attend Vasculata.
The goal of this program is two-fold:

  1. To retain junior (undergraduate, graduate, and postdoctoral fellows) in the field of vascular biology by keeping them engaged. 
  2. To continue the educational process initiated with their attendance at Vasculata 

How will the mentoring program work?  
We will collect information from mentors via an online form. That information will be transferred to the Vasculata mobile event app.  Mentors will be given access to the app and must upload it to a mobile device in order to get notifications of potential mentees.   

Potential mentees will see a listing of mentors and be able to view the provided information (bio, research interests, etc.).  Within the meeting’s mobile app, mentees will be able to reach out to mentors.  Attendees will request a connection with a mentor – once a mentor agrees to connect, they will have access to each other's email address.  After that, mentors and mentees can decide together how they will communicate.

If you are willing to participate as a mentor, please follow this link and submit the following information:

  • Your photo* (you will be able to upload files)
  • A description of your research and scientific interests (include model system, disease, area of focus – see sample)
  • Keywords – up to five that relate directly to your scientific expertise
  • URL to your lab or department
  • Twitter, LinkedIn other social media accounts* (so that your mentee can begin to follow you)
  • The level you would prefer to mentor (undergraduate, graduate student, clinical fellows, postdoc, etc.)

*optional

Mentors will be recognized and thanked at Vasculata.

If you have any questions, please feel free to contact Bernadette Englert - This email address is being protected from spambots. You need JavaScript enabled to view it.

Potential Mentees:

You must attend Vasculata 2019 at the Medical College of Wisconsin this July 15-18.  Once registered you will receive access to the meeting's mobile app.  Mentors will be listed in the app and you will be able to reach out to them through the app.  Once a "connection" is made, you and your mentor can agree upon any means of communication. 

Feedback:

As this is a new program, we will request feedback from both mentors and mentees.  We will send you a brief questionnaire at the following intervals: six months after the start, one year after the start, once a year for five years after the start.  This information will be invaluable to us and our junior colleagues in the vascular biology community.  Based on your feedback we will be able to enhance and/or improve the program accordingly.  Thank you in advance for your cooperation in this regard.

YouTube Channel

NAVBO YouTube Channel

 

Educational Videos in: 

Vasculogenesis/Angiogenesis
VEGF/VEGFR2
Stroke
Aneurysm/Atherosclerosis
Tumor Angiogenesis
Anatomy and Physiology

 

If you have found vascular biology videos that have been beneficial to you, please send us the link (This email address is being protected from spambots. You need JavaScript enabled to view it.). We may be able to add it to one of our existing playlists or create a new playlist

 

Meet Our 2018 Travel Award Recipients

Learn a little more about the 2018 NAVBO Travel Award Recipients

Members of the NAVBO Membership Committee are holding interviews with our recent travel award recipients to find out a little bit more about them, what brought them to NAVBO and what their future will bring.

Mabruka Alfaidi, Louisiana State University Health Sciences Center

 

Mabruka stands with Drs. Masanori Aikawa and
Bill Muller as she is presented with her Travel
Award at Vascular Biology 2018

VB2018 14In a recent interview with Dr. Arif Yurdagul of the NAVBO Membership Committee, Mabruka shared some of her meeting experiences. 

How did you first learn about NAVBO?
I had originally wanted to attend the AHA meeting in 2014 to present my work outside the UK, but my mentor at the time, Dr. Sheila Francis, suggested that the NAVBO conference may be better-suited for what I wanted. Upon my abstract being selected to present an oral presentation, I’ve been a member since then.

Tell us about the research you presented and your mentor?
I was interested in different aspects of endothelial cell biology and when I attended NAVBO in 2014 I met Dr. Wayne Orr, who was investigating how endothelial cells responded to different types of shear stress. Along with Dr. Martin Schwartz, he defined how the extracellular matrix impacted proinflammatory responses and identified Pak and Nck as central players in these pathways-where Pak/Nck association promoted both NF-kB activation and endothelial cell permeability. We’ve since identified various roles for different Nck isoforms in response to shear stress in vitro and in vivo.

What was your favorite event at the meeting?
The nanotalks were by far my favorite event - even though the talks were about 5 minutes long, I was able to learn so much.

Did you meet any people at the meeting who influence your research?
I met Dr. Masanori Aikawa, I’ve always looked up to him. At my poster, I managed to talk and receive feedback from many scientists that have a great impact on my research, including Drs. Yun Fang, Filip Swirski, and Carlos Fernandez-Hernando.

What benefits did the travel award have for you?
The recognition was extremely positive. I received much more attention at my poster than I’ve had in previous meetings. Furthermore, because of the travel award, I'm now able to go to another meeting to further discuss my work. Without the NAVBO travel award, this would have been much more difficult.

What benefits can a trainee expect from attending NAVBO?
The culture that has been cultivated at NAVBO allows for great interactions between senior scientists and trainees, especially meetings at lunch and dinner times. The trainees get a lot of attention, which helps us move toward the next steps in our careers. In addition to attending meetings, I also feel like I contribute-something that has been very rewarding by having a one on one time during the poster sessions.

What future goals do you have for your work?
Build on the work I presented at the NAVBO meeting and publish the work. Also apply for different transition grants.

And, how can NAVBO help you achieve these goals?
By presenting my work at the meeting, I received questions that I didn’t consider before - this has allowed me to substantiate some of the results I got. I’ve also received advice from senior investigators that has allowed me to better strategize my career plans.

Contributor:  Arif Yurdagul, Columbia University 
Published December 13, 2018 - NAVBO NewsBEAT


Thanh Theresa Dinh, Stanford University

 

Theresa stands with Drs. Masanori Aikawa and
Bill Muller as she is presented with her Travel
Award at Vascular Biology 2018

VB2018 15In a recent interview with Dr. Mary Wallingford of the NAVBO Membership Committee, Theresa shared some of her meeting experiences.

How did you first learn about NAVBO?
I first learned about NAVBO while looking for pertinent conferences in my field.

Tell us about the research you presented?
I am looking at the role of two transcription factors and how they act on the molecular level to modulate high endothelial cell identity,a specialized type of EC that is imperative for leukocyte trafficking.

How did your mentor facilitate this work?
My mentor supports me through guidance of my research, monetary assistance and is a sound board of my ideas and hypothesis.

What was your favorite event at the meeting?
The poster session.

Did you meet any people at the meeting who influence your research?
Yes, I was able to hear/meet Paul Kubes, Courtney Griffin, Karen Hirschi and William Muller. Courtney, especially, was able to give me insight on the academic process and being a mother while juggling her career.

What benefits did the travel award have for you?
It allowed me to attend the conference and listen to leaders of the field speak. In addition, I was able to present my research and get direct feedback on my work. All things I would not have been able to do had I not gotten the travel award.

What benefits can a trainee expect from attending NAVBO?
The opportunity to network and develop collaborations with other members in the field.

What future goals do you have for your work?
To publish in a high impact journal and obtain a faculty position!

And, how can NAVBO help you achieve these goals?
To provide more networking opportunities.

Contributor: Mary Wallingford, Tufts Medical Center
Published January 10, 2019 - NAVBO NewsBEAT


Nadiya Khyzha, University Health Network at the University of Toronto

 

Nadiya Khyzha

NadiyaKhyzha 2In a recent interview with Dr. Mary Wallingford of the NAVBO Membership Committee, Nadiya shared some of her meeting experiences.

How did you first learn about NAVBO?
From my lab. Our lab is heavily focused on vascular endothelial cell biology so attending NAVBO is almost a yearly tradition. There's typically at least one person from the lab attending every year.

Tell us about the research you presented?
My research looks at the regulation of NF-kB signalling via non-coding mechanisms in endothelial cells. The project that I've presented focused on the role of long non-coding RNAs in acute inflammation and seeing how they fine tune the expression of their neighboring protein coding genes.

How did your mentor facilitate this work?
Working on long non-coding RNAs was something completely new in my mentor's lab and in Toronto in general. So, my mentor was very open minded and supportive to try a new avenue of research. I was also given a lot of freedom to play around with different ideas and to establish techniques not previously available in the lab. Perhaps it meant that the project took longer to complete but that was critical for my development as a scientist.

What was your favorite event at the meeting?
I'd say the poster sessions and other networking events. It's always nice to meet people and learn about research that's outside the scope of what I'm normally thinking about.

Did you meet any people at the meeting who influence your research?
For sure! My research tends to be very molecular based, so it's easy to get caught up in my own niche and lose perspective of the big picture. I find that a lot of the talks at NAVBO take me out of my lncRNA bubble and make me think about how my research applies to vascular biology in the grand scheme of things.

What benefits did the travel award have for you?
Being able to present my work to a wide group of audience has been a really great way to gain exposure for my project. Also, the 2018 meeting had a few researchers working on noncoding RNAs so it was great to get their opinion on my project.

What benefits can a trainee expect from attending NAVBO?
Attending NAVBO is a great opportunity to present your work and get valuable feedback on it. The size of the NAVBO meeting is also perfect to meet people and to form collaborations.

What future goals do you have for your work?
Getting it published!

And, how can NAVBO help you achieve these goals?
The lack of community of lncRNA researches in Toronto has been one of the big challenges during my PhD. So, international events like NAVBO are always exciting because it's an opportunity to meet other researchers working on lncRNAs. Now that I'm trying to wrap up my paper, NAVBO has provided me a great opportunity to get that last-minute feedback on my work from other lncRNA researchers.

Contributor: Mary Wallingford, Tufts Medical Center
Published January 24, 2019 - NAVBO NewsBEAT


Monica Lee, University of Illinois in Chicago

 

Monica stands with Drs. Ondine Cleaver and
William Sessa as she is presented with her Travel
Award at Vascular Biology 2018

MonicaLeeIn a recent interview with Randa Breikaa of the NAVBO Membership Committee, Monica shared some of her meeting experiences.

How did you first learn about NAVBO?
I learned of NAVBO during my postdoctoral training when my research began to delve into angiogenesis. Several faculty at my current research center were also actively involved with the organization, which largely helped with exposure to NAVBO.

Tell us about the research you presented and your mentor?
My postdoctoral work is centered around understanding the role of endothelial function in vascular homeostasis, namely in the context of Akt signaling. This was a naturally fitting topic for my training given the seminal work done on the Akt-eNOS kinase-substrate relationship achieved by my mentor, Dr. William C. Sessa. My current research is now focused on addressing how endothelial-specific Akt activity contributes to atherosclerotic disease progression.

What was your favorite event at the meeting?
I thoroughly enjoyed the poster sessions in the evenings. The set up provides a great atmosphere for scientific discussion amongst researchers at all levels, providing opportunities for networking and future collaborations.

Did you meet any people at the meeting who influence your research?
My current interests on endothelial Akt signaling seems to relate in part with many research interests of others, likely due to the vast influence of endothelial tissue in all organ function. This led to many engaging discussions at the meeting, allowing myself to see my own research from alternative perspectives.

What benefits did the travel award have for you?
The travel award helped promote my science and generate discussion on my presented research.

What benefits can a trainee expect from attending NAVBO?
The NAVBO conferences are a great opportunity to meet researchers at all levels in both your immediate and adjacent fields. The size of the conference is also one that allows for direct scientific interaction amongst the trainees and the thought leaders of the field.

What future goals do you have for your work?
Cardiovascular disease pathogenesis is preceded by the hallmarks of endothelial impairment, where several high-impact diseases are heavily associated with Akt dysregulation. I hope that my ongoing investigation into endothelial-specific Akt signaling will make a positive contribution to our current understanding of vascular health.

And, how can NAVBO help you achieve these goals?
The NAVBO meetings are a great venue to both present your research and to gain knowledge in all areas of vascular biology. I hope my involvement with NAVBO will continue to provide opportunities to share my research, while invoking scientific curiosity in the upcoming generation of academic scientists.

Contributor: Randa Breikaa, Nationwide Children's Hospital
Published February 21, 2019 - NAVBO NewsBEAT


Tvisha Misra, Sickkids

 

Tvisha Misra

MisraTvishajpgIn a recent interview with Dr. Mary Wallingford of the NAVBO Membership Committee, Tvisha shared some of her meeting experiences.

How did you first learn about NAVBO?
I learned about NAVBO from word of mouth from colleagues and also from my mentor who encouraged me to attend and present my work and learn more about the field.

Tell us about the research you presented?
In the Scott lab I am looking at the role of ccm3in early development and disease. Cerebral cavernous malformations (CCM) are focal dilations in the cerebral vasculature leading tohaemorrhaging, strokes and in extreme cases death. Of the three proteins associated with CCMs, CCM1/2/3, loss of CCM3, a highly conserved scaffold protein, leads to the most severe form of the disease. Though various models have been used to study endpointvascular defects, not much is known about the earliest cellular events which eventually lead to CCMs. We use the zebrafish as a vertebrate model to understand the role of Ccm3 in early vascular development and disease progression. I used CRISPR/CAS9 to generateand characterise vascular defects in ccm3mutant models. A lot of my work focuses on time lapse imaging of developing blood vessels in early embryos to characterise when and how the vascular defects arise. Ccm3 has no known enzymatic activity and isproposed to function as a scaffold protein. Our collaborators in the Gingras lab (author list from the abstract), conducted BioID to find interaction partners (the ‘interactome’) of Ccm3. We selected the strongest candidates to probe their role in vasculardevelopment through generating CRISPR/CAS9 mutants. I am, thus, establishing a model to study Ccm3 function in vivoover time, and, probing Ccm3 function and mechanism of action through understanding the role of its interaction partners in vascular development.

How did you mentor facilitate this work?
Dr Scott has always been very supportive of my choice of project and the methods I use to address my questions. He has always encouraged me to develop the projects in directions where my own interests lie and is always available for scientific input. He has also always encouraged me to attend various conferences and present my work to get as much exposure in the community as I want.

What was your favorite event at the meeting?
For me it was the lunch with PIs on day 2. Many times we do not get to interact with people who are not directly related to our own fields specially if we are presenters (posters give a bit more one on one interaction time, I suppose), and most interactions are limited to the science we present. An event like this gave us the chance to talk not just about our research and results but future prospects in academia and the individual PIs’ philosophies relates to various scientific careers and possibilities. As trainees looking to stay in an academic research environment such input is very useful. All the trainees I talked to also really enjoyed the lunch and we were hoping that we could have more such events in the future.

Did you meet any people at the meeting who influence your research?
Absolutely. Interestingly, during my journey from the airport to the resort I was assigned to a car with a group leader whose recent work relates directly with my current project and part of what I presented at the conference and I had a wonderful time discussing my results with him. Just after my talk I was approached by another group leader who talked in length to me about my work and gave his input on various aspects of my project. It was great to have these one on one discussions with various experts in the field.

What benefits did the travel award have for you?
As a postdoctoral fellow in my third year, I look for every opportunity to present my work and learn as much about the field as possible. Travel awards like these allow me to attend more such meetings than the usual limited funding would allow. Of course, such awards also contribute towards building my scientific portfolio for my future.

What benefits can a trainee expect from attending NAVBO and how can NAVBO help you achieve these goals??
Smaller, more specialized conferences such as NAVBO give trainees like us the opportunity to communicate with the leaders of our fields in a closer setting than what one experiences at bigger meetings. I really enjoyed talking to some members who had been attending the conference for many years and seeing the sense of community that has built up in that time. Everyone I talked to were very positive about their experiences and since I am interested in pursuing a career in basic research in an academic environment I look forward to attending more NAVBO conferences in the coming years.

What future goals do you have for your work?
My interest in the vascular system started with my work with drosophila tracheal development during my doctoral work, which I translated to studying the vascular system in fish for my postdoctoralproject. I am fascinated by the mechanisms that control vascular development and maintenance of proper cardio-vascular function, and the zebrafish, for me, provides a great model to study this using advanced genetic and microscopy techniques. I hope to continue to conduct such research in an academic environment in the future as well.


Tvisha's abstract:
Cerebral cavernous malformations (CCM) are focal dilations in the cerebral vasculature leading to haemorrhaging, strokes and in extreme cases death. Of the three proteins associated withCCM, CCM1/2/3, loss of CCM3, a highly conserved scaffold protein, leads to the most severe form of the disease. Though various models have been used to study endpoint vascular defects, not much is known about the earliest cellular events which eventually leadto CCMs. We use the zebrafish as a vertebrate model to understand the role of Ccm3 in early vascular development and disease progression. With CRISPR/CAS9 we generated a ccm3a/bdouble mutant.ccm3a/b(-/-)embryos exhibit cardiac edemas,loss of blood flow, and embryonic lethality. Time lapse imaging was used to characterise defects in endothelial cell migration, lumen formation, blood flow, and membrane dynamics. To explore the mechanism of Ccm3 function, BioID was used to determine the potentialinteractome of Ccm3. Cellular Ccm3 resides mostly in the striatin interacting phosphatasesand kinase (STRIPAK) complex. We generated CRISPR/CAS9 mutants of these components of the STRIPAK complex, consisting of largely unstudiedgenes, to assess their role in vascular development and their relationship to Ccm3. CCM disease progression is strongly linked to RhoGTPase activity. We determined that unlike Ccm1/2, which act via Rho, Cdc42 is implicated in Ccm3 function: ccm3a/bKOembryos show aberrant Cdc42 activity and KO/KD of cdc42leads to transient cerebral haemorrhages in embryos. Altogether, we have established a model to study early changes in Ccm3 deficient endothelial cells and probe mechanisms of function of Ccm3 invivo.

Contributor: Mary Wallingford, Tufts Medical Center
Published January 10, 2019 - NAVBO NewsBEAT


Ajit Muley, Columbia University Medical Center

 

Ajit stands with Drs. Ondine Cleaver and
William Sessa as he is presented with his Travel
Award at Vascular Biology 2018

Muley2In a recent interview with Mabruka Alfaidi of the NAVBO Membership Committee, Ajit shared some of his meeting experiences.

How did you first learn about NAVBO?
The first time I learned about NAVBO was during my PhD training in India in 2006, when my mentor, professor Suvro Chatterjee, recommended that I attend International meetings. NAVBO was one of the best conferences to go to in the Vascular Biology field. I have become a regular member since then.

Tell us about the research you presented and your mentor?
My mentor is Dr. Carrie Shawber, she is an expert in NOTCH signaling in lymphatic vessels. When I joined the lab, we wanted to understand the molecular mechanism of the metalloprotease MMP14 in lymphatic vessel pathophysiology. We found that MMP14 regulates Lymphatic endothelial cell proliferation during the development of the lymphatic system. When we looked further into this unique phenomenon, we found that MMP14 regulates the activation of ERK signaling in vitro and in vivo to control cell proliferation. Furthermore, patients suffering from hyperplastic lymphatic malformation lost MMP14 expression from their lymphatic vessels, suggesting loss of LEC MMP14 expression may contribute to the pathological increase in proliferation observed in lymphatic malformations. Our on-going works in this area bring to light a key regulator of the Lymphatic malformation pathology and aims to identify novel therapeutic modality for this disease.

What was your favorite event at the meeting?
The Lymphangiogensis session by far was my best favorite. I learnt a lot and was able to interact and received feedbacks.

Did you meet any people at the meeting who influence your research?
There were quite a few people I was looking forward to meeting and luckily NAVBO vascular biology meeting 2018 was very helpful for me. I met Dr. Sathish Srinivasan and Prof. Holger Gerhardt and was able to discuss common research interests at length. There were many other scientists from across the globe that I met during the conference as well.

What benefits did the travel award have for you?
It helped me by covering part of the travel expense to NAVBO and helped me in attending NAVBO with my lab members.

What benefits can a trainee expect from attending NAVBO?
Research experience is definitely great at NAVBO. I personally gained a lot from NAVBO. I shared my data, hypothesis and got the prospect of how to plan and design critical experiments. Moreover, the one to one interaction between scientists for collaborations and networking is very helpful in building long lasting partnerships.

What future goals do you have for your work?
My goal for the current research project is to extend the understanding of MMP14 and its role in lymphatic development. The current work is a part of my mission to identify precision diagnostic and therapeutic targets for lymphatic pathologies and design tailored therapeutic modalities for the patients.

And, how can NAVBO help you achieve these goals?
NAVBO meetings provide a platform for vascular biologists from different focus areas to come together and collaborate freely. Scientists and scholars get to enhance discussion and promote collaboration. This creates a platform to experience different perspectives including vascular biology, genetics and signaling.

Contributor: Mabruka Alfaidi, LSU Health Sciences Center
Published January 24, 2019 - NAVBO NewsBEAT


Brian Sansbury, Harvard Medical School in the Brigham and Women's Hospital

 

Brian stands with Drs. Masanori Aikawa and
Bill Muller as he is presented with his Travel
Award at Vascular Biology 2018

SansburyBrianIn a recent interview with Mabruka Alfaidi of the NAVBO Membership Committee, Brian shared some of his meeting experiences.

How did you first learn about NAVBO?
I first learned about NAVBO in 2015 shortly after beginning my postdoc. I was looking for a vascular-focused meeting to share the findings of our latest study and NAVBO was recommended by my mentor. I presented at the pre-conference meeting for trainees and also presented a poster later in the meeting. It was a wonderful meeting and I was very excited to be able to attend again in 2018.

Tell us about the research you presented and your mentor?
I work in the lab of Dr. Matthew Spite in the Center for Experimental Therapeutics and Reperfusion Injury at Brigham and Women's Hospital and Harvard Medical School where we focus on better understanding the role of lipid mediators in the regulation of inflammation. My project looks specifically at how a class of lipid mediators, the resolvins, modulates tissue repair mechanisms in macrophages to enhance recovery from vascular injury.

What was your favorite event at the meeting?
I would say that the evening poster sessions were my favorite parts of the meeting. Not only do you get to see a vast array of impressive studies, you get to meet and network with other attendees. These types of supportive and collegial interactions are the real draw to the meeting for me.

Did you meet any people at the meeting who influence your research?
Absolutely. NAVBO does an unbelievable job putting together a program that includes so many leaders of multiple fields that it's hard not to meet or see someone that has influenced your work. Even better, most of these individuals are true teachers and mentors and are always willing to give valuable feedback and advice to trainees.

What benefits did the travel award have for you?
As a postdoc, you don't always have a lot of opportunity to present your work in a formal setting. So I jump at any chance that I get. I was lucky enough to travel to an international meeting earlier in the year to present to a non-vascular crowd. While this was a wonderful experience, it completely cleared out my travel funds for the year. Without this travel award I would not have had the resources to attend this meeting at all.

What benefits can a trainee expect from attending NAVBO?
There are several benefits that trainees gain from attending NAVBO in both the scientific and career development areas. Scientifically, you have the opportunity to hear about the cutting-edge work that is being done in vascular biology while also being able to present your own results and receive feedback from some of the most influential people in the field. Additionally, the structure of the meeting and its approachable size make it perfect for networking and meeting potential collaborators.

What future goals do you have for your work?
This project, specifically, is being finalized and submitted for publication soon. In the larger sense, our goals are to continue to advance our understanding of the role that lipid mediators and pro-resolution pathways play in chronic inflammatory diseases to inform the future development of novel therapeutics.

And, how can NAVBO help you achieve these goals?
This year's program included a new Joint Session: Resolution of Inflammation which was a great opportunity to introduce resolution physiology to the vascular community. Continuing to support and highlight the importance of resolution of inflammation in vascular disease at this meeting would facilitate greater collaboration and progress in combating chronic inflammation in vascular disease.

Contributor: Mabruka Alfaidi, LSU Health Science Center
Published February 21, 2019 - NAVBO NewsBEAT


Keith Strand, University of Colordo Anschutz Medical Campus

 

Keith Strand

KeithStrandIn a recent interview with Randa Breikaa of the NAVBO Membership Committee, Keith shared some of his meeting experiences.

How did you first learn about NAVBO?
I first learned about NAVBO in 2016 when I attended the 19th International Vascular Biology Meeting in Boston, MA. My previous research had been in neuroscience, so IVBM 2016 was a great opportunity to get exposure to the broader field of vascular biology outside of the research being done on campus at UC-Anschutz.

Tell us about the research you presented and your mentor?
My mentor is Dr. Mary Weiser-Evans, and I joined her lab as a graduate student in July 2016. Research in the Weiser-Evans lab focuses on understanding how SMCs contribute to pathological vascular remodeling in the context of diseases such as atherosclerosis and hypertension. Dr. Weiser-Evans has shown that PTEN plays an important role in maintaining SMC homeostasis and through both phosphatase dependent and independent effects. Additionally, the Weiser-Evans lab found that SMC-specific loss of PTEN exacerbates vascular remodeling in pre-clinical animal models and that reduced PTEN expression is associated with increased atherosclerotic lesion severity in human coronary vessels. However, our research also indicates that systemic PTEN upregulation reduces pathological vascular remodeling. These data suggest that PTEN upregulation could serve as a novel therapeutic approach to treat vascular disease.

The research that I presented at the Vascular Biology 2018 meeting was related to a high-throughput compound screen that we undertook using a PTEN promoter-reporter system to identify novel compounds that cause PTEN upregulation in SMCs. Our aim was to identify compounds that cause increased PTEN expression with the goal of developing them as novel therapeutic agents to treat vascular disease. In our screen, we tested roughly 3,400 compounds and narrowed our results down to identify 5 compounds that upregulate PTEN expression in SMCs. We are currently testing these compounds for efficacy in preventing remodeling using pre-clinical mouse models of vascular disease.

What was your favorite event at the meeting?
My favorite events were the poster sessions. I enjoyed being able to present my findings, get feedback from the other meeting attendees and see the wide variety of research that other people were presenting in their posters.

Did you meet any people at the meeting who influence your research?
While I didn't meet any particular individual that directly influences my research at this meeting, I was able to take some of the ideas that were presented in talks or posters back to my lab and I think they might be valuable to inform our future research. The talks that I enjoyed the most were Peter Libby - The academic perspective: From bench discovery to clinical trials; Rakesh Jain - Reengineering the tumor microenvironment to improve cancer treatment: Bench to bedside; and Kenneth Walsh - Clonal hematopoiesis: Altered communication between the bone marrow and the vasculature.

What benefits did the travel award have for you?
The travel award covered the cost of my airfare and ground transportation to the conference, so it really helped get me to the meeting and gave me a chance to present my research there. It took a huge chunk out of the total cost for attending the meeting, which made it much more feasible for me to come from Denver.

What benefits can a trainee expect from attending NAVBO?
I have attended two meetings organized by NAVBO, IVBM 2016 and Vascular Biology 2018. As a trainee, I appreciated the wide range of topics presented at both meetings. I thought the meetings were very valuable to help me keep up to date with current research in the field, and gain exposure to new ideas because of the amount of recently published, or unpublished data presented at both conferences.

What future goals do you have for your work?
My short term goal is to finish up the research that I presented at the conference and identify potentially clinically relevant compounds to treat vascular disease in people. After graduation, I want to continue research in the field of vascular biology as a post-doc and see where that takes me.

And, how can NAVBO help you achieve these goals?
At a smaller level, the opportunity to earn travel awards offered by NAVBO goes a long way to help me attend these national/international meetings. In a broader sense, NAVBO provides great opportunities for networking with other PIs and presenting my research at conferences, which will hopefully help me with the next steps after graduation.

Contributor: Randa Breikaa, Nationwide Children's Hospital
Published February 7, 2019 - NAVBO NewsBEAT


Amber Stratman, Washington University in St. Louis

 

Amber Stratman

AmberStratmanIn a recent interview with Mabruka Alfaidi of the NAVBO Membership Committee, Amber shared some of her meeting experiences.

How did you first learn about NAVBO?
I first learned about NAVBO as a graduate student when I was in George Davis's Lab at the University of Missouri. He encouraged me to attend to Vascular Biology meetings, and that's why I applied to the NAVBO Developmental Vascular Biology Meeting in 2008. I have attended regularly ever since.

Tell us about the research you presented and your mentor?
At the last NAVBO meeting, I presented a new project I have been working on which involves a zebrafish mutant identified in a forward genetic mutagenesis screen. The zebrafish mutant is genetically deficient in a dynein light intermediate chain, DYNC1LI1, leading to exacerbated blood vessel formation. We are currently investigating the underlying molecular mechanism behind this phenotype, in order to define this gene's role during vascular development and understand if there are any clinical implications. This work has been done under the mentorship of Dr. Brant Weinstein at NICHD, NIH. He's one of the pioneers of using zebrafish to study vascular biology, and I've learned a tremendous amount about zebrafish vascular imaging, mutagenesis screening, and developmental biology under his mentorship.

What was your favorite event at the meeting?
I really enjoyed the poster sessions. You get the chance to talk with people one on one and really dive in to how they are thinking about their research. For me, this sometimes stimulates new lines of thinking and can highlight alternative approaches to challenging experimental problems I am struggling with.

Did you meet any people at the meeting who influence your research?
I feel by going to NAVBO, I always meet the people who are influencing my research. It's organized in an intimate setting, therefore, you cannot help but meet the PIs in the field who are important to your work. One person who I got to speak and interact with during the lunch and learn session was Dr. Christer Betsholtz. During this session, the group got to learn more about his recent extensive single cell RNA-seq work.

What benefits did the travel award have for you?
It raises the possibility for me to attend other new meetings that I have not got the chance to attend in previous years.

What benefits can a trainee expect from attending NAVBO?
The biggest thing a trainee can benefit from by attending NAVBO, besides the cutting edge science and the opportunity to present their work, is the chance to network and meet other people who are doing a similar work in the field. Put a face with a name. Because, its such an interactive meeting, you really have the chance to get to know people.

What future goals do you have for your work?
I recently accepted an assistant professor position at Washington University in St Louis. My biggest future goal at the moment is to get transitioned to my new position, and start doing science driven by both my previous research background as well as new directions I hope to develop.

And, how can NAVBO help you achieve these goals?
NAVBO has been integral for me in achieving my goals. It has always been such a tremendously supportive Society. By coming to the meetings, I have been able to meet and connect with people from a broad, international background in the field. The meetings have given me a platform to share my science, put out new ideas, and receive critical feedback to refine my work moving forward.

Contributor: Mabruka Alfaidi, LSU Health Sciences Center
Published February 7, 2019 - NAVBO NewsBEAT


 

2017 Business Meeting Minutes

Membership Business Meeting
October 18th, 2017-Monterey, CA

Dr. Jan Kitajewski, NAVBO Past President, called the meeting to order at 2:00p.m. Dr. Michelle Bendeck, University of Toronto, moved to approve the minutes from the 2016 meeting and it was seconded by Yun Fang, University of Chicago and all were in favor.

Dr. Kitajewski began by thanking all those that helped to make Vascular Biology 2017 a success and acknowledged supporters: NHLBI, Genentech, Regeneron, the University of Washington’s Department of Bioengineering and Science Signaling (AAAS). He also gave a special thanks to the University of Toronto and the Ted Rogers Heart Institute for providing additional travel awards in recognition of the 10th Anniversary of the Vascular Matrix Biology and Bioengineering Workshop.

He also thanked our exhibitors for their participation: Applied BioPhysics, Bio-Techne, Biometrology, VisualSonics, ibidi, Lonza and PromoCell.

Dr. Kitajewski mentioned that we are in the midst of a fantastic meeting, that he had heard wonderful feedback and he thanked the meeting organizers – Vicki Bautch and Brian Black for the Developmental Vascular Biology and Genetics Workshop and Drs. Jessica Wagenseil, Craig Simmons, Marlene Rabinovitch and Kayla Bayless for the Vascular Matrix Biology and Bioengineering Workshop. He also noted special sessions included in the program this year and thanked Juan Melero-Martin and Weilan Ye for organizing those sessions.

At this time, Dr. Kitajewski announced results of the vote that took place at the meeting via the event app. Dr. Courtney Griffin was elected as the Co-Organizer of the Developmental Vascular Biology and Genetics Workshop (working with Dr. Bautch) and Drs. Chris Breuer and Linda Demer will co-organize the Vascular Matrix Biology and Bioengineering Workshop (with Drs. Bayless and Rabinovitch). He thanked Drs. Bischoff, Chen and Rongish for their willingness to run.

The Meritorious Awards recipients were also acknowledged and everyone was encouraged to remain for their lectures, which followed the meeting. A list of the Travel Award recipients was displayed on the screen and we were reminded that they received their awards on Sunday evening. Dr. Kitajewski also thanked the NAVBO Council and informed the group that due to a family emergency, Dr. Giachelli had to leave the meeting suddenly. He thanked the NAVBO staff, Ms. Englert and Ms. Danielle Pinkel who work year round; Ms. Anita Pustelnik who has joined the staff recently and works exclusively with the Education Committee to further their initiatives and finally, Ms. Orth-Pallavicini was thanked for her work at the meeting as well as past meetings.

At this time in the program, Dr. Kitajewski asked Dr. Michelle Bendeck to come up and give a memorial for Elaine Raines. Many members of the group were aware of her passing in July. Dr. Bendeck in addition to her own testament, read Dr. Giachelli’s memoriam recognizing Dr. Raines’ very active participation within NAVBO over many years (councilor from 2007-2010; early editor of the Publications Alert; 2013-2015 Meritorious Awards Committee member; 2015-present, Chair of the Awards Committee) but spoke mostly of Dr. Raines as a role model for so many trainees at UW, who had carried on the legacy of the her mentor, Russell Ross; Dr. Giachelli was a long-time colleague of Dr. Raines and her passing left a great void in the Dept of Pathology at the University of Washington, but is also a great personal loss to Dr. Giachelli as well as many others in attendance. Dr. Bendeck noted that Dr. Raines was a role model for her when she was a postdoc at the University of Washington, she noted that at the time there were very few women in the field. She then asked for a moment of silence.

Since Dr. William Muller, Secretary-Treasurer, was not able to attend the meeting, Ms. Englert gave both the financial and membership reports. Overall Ms. Englert reported that NAVBO is financially sound. She pointed out that the profit in 2016 is a bit misleading since many of the speakers of the IVBM were not reimbursed for travel until after January 1, 2017. She added that most likely this will cause us to show a loss in 2017. However, she noted that the IVBM was a resounding success and that $50,000 of the profits has already been put aside to help fund the 2022 IVBM, which NAVBO will host. In addition, NAVBO plans to support eight travel awards at $1,200 each to the 2018 and 2020 IVBMs to support greater representation of North Americans at the European and Asian venues. She expects the 2017 meeting to break even. (Figures are available in the slideshow). Dr. Bautch noted that NAVBO also supports travel awards to certain Gordon Conferences.

The Membership Report showed an increase in membership in 2016, however, Ms. Englert attributed that to the IVBM. She reported that although the NAVBO membership sometimes spikes to almost 1,000, the sustained number is closer to 800, where approximately 500 are regular members and 300 are trainees.

Dr. Kitajewski acknowledged that there was a large number of attendees from overseas and thanked them for joining us. He noted that when the IVBM is held outside of North America there are not enough attendees from the US. He encouraged all to attend the 2018 IVBM in Helsinki in June.

Dr. Kitajewski named upcoming NAVBO meetings – Vasculata 2018 in St. Louis and added if any site were interested in hosting future NAVBO meetings to contact Ms. Englert. Vascular Biology 2018 will focus on Signaling and Inflammation and will be in a new site in Newport, RI. Lymphatic Forum 2019 is once again being co-sponsored with LE&RN and will be held in the Spring in Austin, TX.

He asked for a show of hands concerning the 2019 Vascular Biology meeting and if it should be held at Asilomar. The majority (60 out of 70) want it to return to Asilomar.

Dr. Bautch asked if NAVBO was still looking to do more meetings similar to the Lymphatic Forum. Dr. Kitajewski responded – yes! NAVBO will partnership with institutions to broaden our scope and help to bring more opportunities to our members.

In speaking about NAVBO’s initiatives in the past year, he mentioned the addition of the member-proposed session. He mentioned that we had a lot of great proposals and that NAVBO will continue this for future meetings. He encouraged members to submit a proposal for 2019.

Other notable initiatives include the addition of trainees to the Membership and Education Committees; several initiatives from the Education committee including a webinar series to start in early 2018; joining Research!America to advocate for science (here he noted that NAVBO may pass on email alerts to members for calls to action regarding policy that affects the NIH, etc.); and affiliation with a new journal, Frontiers in Cardiovascular Medicine. He encouraged members to submit to two Research Topics sponsored by NAVBO – Vascular Calcification and Vascular Progenitors.

Dr. Kitajewski opened the meeting to questions and discussions from the members. Dr. Zorina Galis asked if members would have an interest in updates from NHLBI concerning funding opportunities. Dr. Kitajewski responded with a resounding Yes! Dr. Galis continued that she would be willing to bring people to the meeting to discuss training grants, etc. and that these could be incorporated into the meeting. She added that in 2018 there will be a bioinformatics boot camp at Vascular Biology, which will go over the resources and tools available, how to find them and use them. She added that there is also the project of Mapping the Human Body and encouraged the vascular biology community to apply and collaborate to map the vasculature within different organs. Dr. Kitajewski supported this idea, adding that input from the vascular community is needed for mapping the organs.

In closing, Dr. Kitajewski said that since many of the attendees were not at this business meeting, we would send out a poll concerning returning to Asilomar.

Dr. Kitajewski concluded the meeting by saying that it was an honor to serve as President and now Past President of NAVBO. He then asked the members to interact with the Council and to send them any ideas, etc., he added that the Council is here to respond to your needs. The meeting concluded at 2:30p.m.

 

 

Travel Awards to the Lymphatic Forum 2019

Lymphatic Forum 2019

May 30-June1, 2019
AT&T Conference Center
Austin, Texas

 

Travel and Poster Awards are being provided by the following organizations:

LERN NAVBO              

The Lymphatic Education & Research Network (LE&RN) is offering Travel Awards (20 total of $500 US currency) for young investigators who are LE&RN members (PhD students, medical students and postdocs) to defray registration and travel costs associated with attending the Lymphatic Forum 2019-Exploring the Lymphatic Continuum. In addition, four Best Poster Presentation awards (one $1,000 US currency and three $500 US currency) will be given to the top posters presented. Travel awards are NOT available for local participants (defined as "residing within a 25 mile radius of the meeting venue") to attend the conference.  If you are not yet a member of LE&RN, go to https://lymphaticnetwork.kindful.com/?campaign=329202

The North American Vascular Biology Organization (NAVBO) will present two Travel Awards at $500US each to young investigators (graduate, PhD or medical students, postdoctoral and research fellows or residents) that are members of NAVBO.  Travel awards are not available for local participants (defined as "residing within a 25 mile radius of the meeting venue") to attend the conference. If you are not yet a member of NAVBO, go to http://www.navbo.org/membership/join-navbo   


ELIGIBILITY CRITERIA FOR TRAVEL AWARDS FOR LYMPHATIC FORUM 2019

Deadline extended to April 2.

To apply, prospective candidates must:

  • be actively enrolled in a doctoral program, residency or accredited program of postdoctoral graduate education in the biomedical sciences
  • provide a blog post summarizing the meeting and their experience at the event
  • be a member of LE&RN or NAVBO
  • reside more than 25 miles from the conference

APPLICATION PROCESS
To be considered for a Travel Award, the following information is required: 

  • Submit an abstract to the Lymphatic Forum 2019 (click Abstracts on the left)
  • Provide your Curriculum Vitae (CV) or National Institutes of Health biographical sketch*
  • indicate that you are applying for this award within the online abstract submission form (choose the one with the appropriate society affiliation; you can choose both if you are a member of both societies)

*NAVBO members are required to submit their CV upon membership application; LE&RN members should email their CV to This email address is being protected from spambots. You need JavaScript enabled to view it. by April 2.  

SELECTION PROCESS
Travel award recipients will be determined by a joint society committee after candidates have met all eligibility requirements. Checks will be presented to the recipients at the meeting at a specified date and time, which is yet to be determined.


Meeting Sponsors:           

LERN NAVBO              

Abstract Submission

 

Vascular Biology 2019

Featuring:

Developmental Vascular Biology and Genetics Workshop VII 
and 
Vascular Matrix Biology and Bioengineering Workshop VI

October 27-31, 2019

Asilomar Conference Grounds on the Monterey Peninsula

Abstract Submission Deadline extended to August 12, 2019

 

Please follow the application rules included in the abstract submission guidelines for late-breaking abstracts.

You may submit more than one abstract, however, the same abstract may not be submitted to both workshops.

The organizers will attempt to program all submitted abstracts. NAVBO reserves the right to reject any
abstract. Authors should indicate their preference for either poster or oral presentation, however, due to the limited number of slots within oral sessions, most abstracts will be programmed for poster presentation.

  • Use Arial font, 10 point
  • Abstract titles are limited to 200 characters (including spaces)
  • Abstracts are limited to 1,750 characters (including spaces)
  • DO NOT include the title, authors or author affiliations in the body of the abstract
  • Enter each co-author into the database, be consistent with affiliations and include co-authors' emails, cities, states and countries
  • Additional instructions available here.
  • Poster boards are 4x4 feet (122cmx122cm)

For Junior Faculty

If you are within five years of your first independent investigator position and are submitting an abstract to Vascular Biology, consider applying for the Springer Junior Investigator Award.  See here for details and criteria.


Topic Categories:

Developmental Vascular Biology and Genetics:
Artery-Vein Differentiation
Blood Vessel Morphogenesis
Integrative Function in the Microcirculation
Lymphangiogenesis
Mural Cell Origins and Functions
Origins of the Vasculature
Signaling in the Vasculature
Therapeutic Potential of Induced Pluripotent Stem Cell-derived ECs

Vascular Matrix Biology and Bioengineering:
Bioengineering Organ-Specific Vasculatures
Bioengineering Vascularized Tissues for Regenerative Medicine
Disease Modeling with Biomedical Engineering
Extracellular Matrix and Disease
Genetic Mechanisms Underlying Vascular Disease
Intersection of Tissue Engineering and Computational Modeling
Mechanotransduction
Microphysiological Models of the Microcirculation
Vascular Calcification and Valve Development

Vascular Therapeutics
Emerging Technologies and Imaging

Vascular Biology (poster presentations only):
Animal Models of Vascular Disease
Atherosclerosis and Restenosis
Hypertension/Endothelial-dependent Responses
Lipid Mediators and Lipoproteins
Lymphatic Function
Regulation of Epithelial and Endothelial Junctions
Stem Cells in Vascular Biology
Vascular Inflammation and Immunology
Vascular Signaling
Vascular Smooth Muscle Cell Biology
Other Bioengineering
Other Developmental Biology
Other Genetics
Other Matrix Biology
Other Microcirculation
Other

 

Submit your abstract here

Register for VB2018

register

Vascular Biology

October 14-18, 2018
Gurney's Newport Resort and Marina, Newport, RI

Featuring:

Biology of Signaling in the Cardiovascular System Workshop V

and

Vascular Inflammation Workshop II

 

Registration fees:

Members:

Regular registration: $555 (After August 15 - $625)

Trainee/Student Members: $400 (After August 15 - $450)

Non-members:

All non-members: $685*  (After August 15 - $755)

Regular registration covers NAVBO Regular and Emeritus Members.

Optional:
Trainee Pre-Conference Meeting

All are welcome to attend the Pre-Conference Meeting organized and run by Trainees. There is an additional fee of $25 to attend.

BioInformatics Boot Camp
There is an additional fee to attend this NEW session. ($30 for trainees and $45 for faculty)

Please note that there will be a 3% surchage added for all credit card transactions (see more information about this below).  For wire transfers add $15 to your total payment.  

register

To register by check or offline, download the registration form - Registration Form

Cancellation Policy: Cancellations made, in writing, on or before September 15, 2018, will receive a refund less $100 processing fee. No refunds will be made after September 15.

Registration includes access to all sessions (except the Trainee Pre-Conference Meeting and Boot Camp), morning coffee breaks Monday through Thursday, a Welcome Reception (Sunday evening), lunch on Monday and poster session refreshments on Monday and Tuesday evenings.

*includes complimentary membership in NAVBO through December 31, 2018.  Join NAVBO and save on registration.

Please register by October 11
Onsite registration will be available with a $20 surcharge, but we prefer that you register by October 11.
Thank you.

If you prefer to pay with a check - complete and submit a paper registration form and mail it to:
NAVBO
18501 Kingshill Road
Germantown, MD 20874-2211

Download the Registration Form

Additional Information for International Travelers

For information about acquiring a visa please go here.

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