Multiscale analysis of lymphatic muscle pumping
Lymphatic Forum 2019
Exploring the Lymphatic Continuum
May 30-June 1, 2019
AT&T Conference Center Austin, TX
Preliminary Program
| Thursday, May 30, 2019 | |||
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Clinical Aspects of Lymphatic Pathologies and Patient Perspectives |
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| 8:30am | Clinical cases discussed | ||
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Lymphatic Development and Remodeling |
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10:40am |
Introduction by Session Chair | ||
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10:45am |
Lymphatics in heart development | ||
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Guillermo Oliver, Northwestern University | ||
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11:10am |
Multiscale analysis of lymphatic muscle pumping | ||
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James Moore, Imperial College London | ||
| 11:35am | Leishmania Infection–Induced Lymphangiogenesis | ||
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Tiffany Weinkopff, University of Arkansas for Medical Sciences | ||
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12:00pm |
Short Talk: Nucleoside-Modified VEGFC mRNA Induces Organ-Specific Lymphatic Growth and Reverses Experimental Lymphedema | ||
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Zoltan Jakus, Semmelweis University and Hungarian Academy of Sciences | ||
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12:13pm |
Nano Talk: Lymphatic Mimicry Promotes Placental Spiral Artery Remodeling | ||
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John Pawlak, University of North Carolina | ||
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12:18pm |
Nano Talk: Enhancing Lymphangiogenesis Ameliorates Chronic Heart Failure | ||
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LouJin Song, Pfizer, Inc. | ||
| 12:23pm Lunch Break – on your own | |||
| 1:45pm | Message from Dr. Griffin Rodgers, Director National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | ||
| William Repicci, President and CEO of LE&RN | |||
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Lymph and Interstitial Fluid "omic" Profiles in Health and Disease |
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| 1:55pm | Introduction by Session Chair | ||
| 2:00pm | Continuous release of Beta cell peptides primes the immune system for autoimmune diabetes | ||
| Emil Unanue, Washington University School of Medicine | |||
| 2:25pm | Identification of pathogen peptidome targets in biological fluids to diagnose disease and identify specific pathogen species | ||
| Tony Hu, Arizona State University | |||
| 2:50pm | Short Talk: Ultra high-frequency ultrasound: a new and highly accurate tool for visualization of lymphatic vessels | ||
| Guido Giacalone, AZ Sint-Maarten | |||
| 3:03pm | Nano Talk: Altered lymphatic transport and metabolism of chylomicrons in Crohn’s disease | ||
| Li-Hao Huang, Washington University School of Medicine | |||
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Mechanobiology of Lymphatic Structure and Function |
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| 3:25pm | Introduction by Session Chair | ||
| 3:30pm | The tale of two shear stress activated signaling pathways | ||
| Sathish Srinivasan, Oklahoma Medical Research Foundation | |||
| 3:55pm | Effects of pulmonary lymph flow on lymphatic endothelium | ||
| Sanjeev Datar, University of California, San Francisco | |||
| 4:20pm | Dissecting the transcriptional control of lymphatic endothelial cell identity | ||
| Natasha Harvey, University of South Australia | |||
| 4:45pm | Short Talk: The role of Foxo1 in Lymphatic Valve Formation | ||
| Ying Yang, University of South Florida | |||
| 4:58pm | Short Talk: VE-cadherin Is Required for Lymphatic Valve Formation and Maintenance | ||
| Joshua Scallan, University of South Florida | |||
| 5:11pm | Nano Talk: Ex vivo and In Vivo Entrainment of Lymphatic Contractions to Oscillatory Pressure Gradients | ||
| Anish Mukherjee, Georgia Institute of Technology | |||
| 5:16pm | Nano Talk: Co-regulation of Lymphangiogenesis by Mechanical and Biochemical Cues | ||
| Laura Alderfer, University of Notre Dame | |||
| 5:21pm | Nano Talk: An in vitro study of the morphological and biochemical responses of lymphatic endothelial cells in response to spatiotemporally varying wall shear stress | ||
| Elefttheria Michalaki, Stanford University | |||
| 5:26pm | Dinner on your own | ||
| Poster Session I – 7:30-9:30pm | |||
| Friday, May 31, 2019 | |||
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Mixed Vascular (lymphatic-venous) Anomalies |
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| 8:30am | Introduction by Session Chair | ||
| 8:35am | Molecular Genetics of Vascular Malformations | ||
| Miikka Vikkula, Institut de Duve | |||
| 9:00am | Complex Vascular Malformations with Lymphatic Involvement | ||
| Francine Blei, Northwell Health | |||
| 9:25am | Medical management of lymphatic anomalies: Sirolimus and beyond | ||
| Denise Adams, Boston Children’s Hospital | |||
| 9:50am | Short Talk: RAS-MAPK and PI3K-AKT-mTOR pathway inhibitors in a zebrafish model of lymphatic malformations associated with the KRAS p.G12D mutation | ||
| Sarah Sheppard, Children's Hospital of Philadelphia | |||
| 10:03am | Nano Talk: Mutations in genes involved in MAPK pathway cause lymphatic anomalies | ||
| Dong Li, Children's Hospital of Philadelphia | |||
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Trainee/Young Investigators Session |
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| 10:25am | Introduction by Session Chairs | ||
| 10:30am | Loss of lymphatic endothelial Foxc2 in adult protects against diet-induced obesity by promoting lymphangiogenesis | ||
| Yang Lee, Harvard Medical School/Boston Children's Hospital | |||
| 10:55am | MicroRNA-mediated control of developmental lymphangiogenesis | ||
| Hyun Min Jung, NICHD/NIH | |||
| 11:20am | Dysfunction of collecting liver lymphatics during the progression of extrahepatic cholestasis | ||
| April O'Brien, Texas A&M Health Science Center | |||
| 11:45am | Nanofibrillar scaffold with plated adipose derived stem cells, its use for lymphedema treatment in rats, and path for clinical application | ||
| Peter Tabada, Fibralign Corp | |||
| 12:10pm Lunch Break – on your own | |||
| 1:45pm | Message from Dr. Gary H. Gibbons, M.D., Director of the National Heart, Lung, and Blood Institute (NHLBI) | ||
| William Repicci, LE&RN | |||
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Lymphatic Muscle and Lymph Flow |
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| 1:55pm | Introduction by Session Chair | ||
| 2:00pm | Water intake accelerates mesenteric lymph flow and the total flux of long-chain fatty acids | ||
| Toshio Ohhashi, Shinshu University | |||
| 2:25pm | SR calcium release accelerates lymphatic muscle cell pacemaking through activation of Ano1 | ||
| Scott Zawieja, University of Missouri | |||
| 2:50pm | Early rescue of lymphatic function limits atherosclerosis progression in Ldlr-/- mice | ||
| Catherine Martel, Montreal Heart Institute | |||
| 3:15pm |
Short Talk: Muscle cells on the lymphatics should be referred as lymphatic muscle cells not as lymphatic smooth muscle cells |
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| Mariappan Muthuchamy, Texas A&M University | |||
| 3:28pm | Nano Talk: Role calcineurin/NFAT inhibitors on contractility of collecting lymphatic vessels | ||
| Zhanna Nepiyushchikh, Georgia Institute of Technology | |||
| 3:33pm | Nano Talk: Endothelium-dependent mechanisms of lymphatic dysfunction in metabolic syndrome and type-2 diabetes associated with obesity | ||
| Jorge Castorena-Gonzalez, University of Missouri | |||
| 3:38pm | Nano Talk: Lymphatic-targeting nanoparticles for mechanistically enhancing contractions of collecting lymphatic vessels | ||
| Kim To, Georgia Institute of Technology | |||
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Quantitative Analysis of Lymphatic Structure and Function |
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| 4:00pm | Introduction by Session Chair | ||
| 4:05pm | Physical and electrical analogs of multi-lymphangion systems | ||
| James Baish, Bucknell University | |||
| 4:30pm | In vivo imaging of the outflow of cerebrospinal fluid through lymphatic vessels | ||
| Steven Proulx, Swiss Federal Institute of Technology | |||
| 4:55pm | Growth and remodeling in collecting lymphatic vessels and the consequence to function | ||
| Brandon Dixon, George Institute of Technology | |||
| 5:20pm | Short Talk: Paracellular and energy-dependent transport as functional components of lymphatic physiology of brain meninges | ||
| Liudmila Romanova, Rush University Medical Center | |||
| 5:33pm | Nano Talk: Inadequate Lymphatic Reserve in Heart Failure with Preserved Ejection Fraction | ||
| Giacomo Rossitto, University of Glasgow | |||
| 5:38pm | Nano Talk: Chemokine Transport within the Lymphatic System: Toward an Integration of Cellular and Transport Phenomena | ||
| Daniel Watson, Imperial College | |||
| 5:45pm | Dinner on your own | ||
| Poster Session II – 7:30-9:30pm | |||
| Saturday, June 1, 2019 | |||
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Novel Insights on Mechanisms of Lymph Transport |
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| 8:30am | Introduction by Session Chair | ||
| 8:35am | Histamine and lymphatics - from health to disease | ||
| Anatoliy Gashev, Texas A&M College of Medicine | |||
| 9:00am | Delivering therapeutics to targets within the lymphatics | ||
| Eva Sevick, University of Texas Health Science Center at Houston | |||
| 9:25am | Latest advances in research on lymphatic anomalies with bone involvement | ||
| Michael Dellinger, UT Southwestern Medical Center | |||
| 9:50am | Lymphatics in our unhealthy lifestyles | ||
| Joseph Rutkowski, Texas A&M Health Science Center | |||
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Inflammation and the Lymphatic-immune Interface |
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| 10:30am | Introduction by Session Chair | ||
| 10:35am | Leukocyte entry and migration through afferent lymphatic vessels | ||
| Cornelia Halin, ETH Zurich | |||
| 11:00am | Lymph-borne antigens and dendritic cells in the generation of T cell responses | ||
| Michael Gerner, University of Washington | |||
| 11:25am | Immune consequences of lymphatic alterations during intestinal inflammation | ||
| Pierre von der Weid, University of Calgary | |||
| 11:50am |
Short Talk: Lymph node formation and B cell homeostasis require IKKa in distinct endothelial cell-derived compartments |
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| Michael J. May, University of Pennsylvania | |||
| 12:03pm | Short Talk: Chronic liver disease in humans causes expansion and differentiation of liver lymphatic endothelial cells | ||
| Matthew A. Burchill, University of Colorado - Anschutz Medical Campus | |||
| 12:16pm |
Nano Talk: Mechanisms of immunotherapy potentiation by lymphangiogenic tumors |
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| Lambert Potin, University of Chicago | |||
| 12:21pm | Nano Talk: Lymphatic-mediated egress of tumor-specific CD8+ T cells limits anti-tumor immunity in melanoma | ||
| Maria Steele, Oregon Health & Science University | |||
| 12:26pm Lunch Break – on your own | |||
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Role of Lymphatics in Infectious and Parasitic Diseases |
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| 1:45pm | Introduction by Session Chair | ||
| 1:50pm | Doxycycline trial for filarial lymphedema | ||
| Philip Budge, Washington University in St. Louis | |||
| 2:15pm | Effects of MRSA infections on lymphatic function | ||
| Tim Padera, Massachusetts General Hospital | |||
| 2:40pm | Lymphatic transport in cutaneous viral infection |
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| Amanda Lund, Oregon Health & Science University | |||
| 3:05pm | Short Talk: PD-L1 expression by lymphatic endothelial cells; more than just a signal to T cells | ||
| Beth A. Tamburini, University of Colorado Anschutz Medical Campus | |||
| 3:18pm | Short Talk: Inherent biomechanical traits enable infective filariae to disseminate through collecting lymphatic vessels | ||
| Witold Kilarski, University of Chicago | |||
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Lymphatic Tissue Engineering, Stem Cells and Nanoparticles |
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| 3:45pm | Introduction by Session Chair | ||
| 3:50pm | Tissue scaffolds for reconstruction of lymphatic vessels | ||
| Stanley Rockson, Stanford University | |||
| 4:15pm | Overcoming barriers to tumor lymphatic drug delivery | ||
| Susan Thomas, Georgia Institute of Technology | |||
| 4:40pm | Short Talk: Stromal vascular fraction derived vasculogenesis is associated with the formation of mosaic lymphatic/blood vessels | ||
| Walter Lee Murfee, University of Florida | |||
| 4:53pm | Nano-Talk: Nanoparticles for lymphatic-targeted nitric oxide delivery | ||
| Lauren F. Sestito, Georgia Institute of Technology | |||
| 4:58pm | Nano-Talk: Targeting antigen to lymph node lymphatic endothelial cells under steady-state to promote archiving and memory | ||
| Chitavi D. Maulloo, University of Chicago | |||
| Closing Session | |||
| 5:30pm | Message from Kathy Bates LE&RN Spokesperson and Intro to Plenary Speaker | ||
| William Repicci, LE&RN | |||
| 5:40pm | Plenary Lecture: Translational medicine: the impact of lymphatic science | ||
| Peter Mortimer, St. George’s University of London | |||
| 6:30pm | Farewell Dinner and Award Ceremony | ||
Sponsors:
Translational medicine: the impact of lymphatic science
