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Vascular Biology 2018

Vascular Biology

Newport, RI
October 14-18, 2018

Keynote Lecture by Dr. Paul Kubes 
Imaging sterile inflammation and repair
Sponsored by the Microcirculatory Society

Paul Kubes, Ph.D.
Professor
University of Calgary Medical Center

Workshops:

Biology of Signaling in the Cardiovascular System Workshop V

Organized by Ondine Cleaver, University of Texas Southwestern Medical Center and
William Sessa, Yale School of Medicine

Non-coding RNA: Targets and Mechanisms
Mark Feinberg, Brigham and Women’s Hospital, Harvard Medical School
Endothelial lncRNAs and atherosclerosis
Carlos Fernandez-Hernando, Yale School of Medicine
SREBP/miR-33a/b in cardiometabolic diseases

Intersection of Lipid Metabolism and Vascular Health
William Sessa, Yale School of Medicine
New insights into vascular control of lipid metabolism
Gwendalyn Randolph, Washington University
Regulation of HDL recirculation from vasculature to the interstitium and back

Neurovascular Niche and Disease
Moderator: Christer Betsholtz, Uppsala University
Anne Eichmann, Yale School of Medicine
Vascular patterning in development and disease
Chenghua Gu, Harvard Medical School
Molecular mechanisms governing the function and regulation of the blood-brain barrier

Signals that Control Angiogenesis and Vascular Remodeling
Lena Claesson-Welsh, Uppsala University 
Signals regulating vascular leakage 
Holger Gerhardt, Max-Delbrueck-Center for Molecular Medicine
Mechanisms and mechanics in vascular patterning

Paracrine Communication between Organs and Vasculature
Moderator: Ondine Cleaver, UT Southwestern
Kenneth Walsh, Boston University
Clonal hematopoiesis: altered communication 
between the bone marrow and the vasculature
Shahin Rafii, Weill Medical College at Cornell
Angiocrine crosstalk between organotypic endothelium and stem cells

Blood Vessel Morphogenesis and Vascular Malformations
Joyce Bischoff, Boston Children’s Hospital, Harvard Medical School 
Capillary malformations: from somatic GNAQ mutation to disrupted endothelial function
Miikka Vikkula, de Duve Institute, University of Louvain
Signaling defects in vascular malformations

Lymphangiogenesis
Mark Kahn, University of Pennsylvania
Integrated mechanisms of vascular development and disease 
Kathleen Caron, University of North Carolina, Chapel Hill
Lymphatics in specialized vascular beds

 

Vascular Inflammation Workshop II

Organized by Masanori Aikawa, Brigham and Women's Hospital, Harvard Medical School and
William A. Muller, Northwestern University

Vascular Permeability in Inflammation
Dolly Mehta, University of Illinois at Chicago
Insights into mechanisms repairing endothelial barrier
Sarah Yuan, University of South Florida
Endothelial barrier regulation in inflammation

Lymphatic Vessels in Inflammation
Melody Swartz, University of Chicago
Lymphangiogenesis in chronic inflammation: protective or pathological?
Donald McDonald, University of California, San Francisco
Lymphatic vessel growth and remodeling in disease

Leukocyte-Endothelial Cell Interactions
Moderator: Klaus Ley, La Jolla Institute for Allergy and Immunology
Christopher V. Carman, BIDMC and Harvard Medical School
Cytoskeletal dynamics in the regulation of leukocyte diapedesis and vascular barrier
William A. Muller, Northwestern University
Signaling pathways that control transendothelial migration: intravital microscopic studies in real time 

Inflammation in Vein Grafts and AV Fistulas
Paul Quax, Leiden University
Inflammation and immune modulation in vein graft remodeling
Masanori Aikawa, Brigham and Women’s Hospital, Harvard Medical School
Global proteomics and systems biology of vein graft and arteriovenous fistula inflammation

What Makes Postcapillary Venules Special?
Moderator: Jordan Pober, Yale School of Medicine
Eugene Butcher, Stanford University
High dimensional single cell profiling of blood vascular endothelial cells: endothelial origins and differentiation in immune angiogenesis
Lydia Sorokin, University of Munster
The role of endothelial basement membrane laminins in shear response in resistance arteries

Bioactive Extracellular Vesicles
Joint Session with ISACB
Susmita Sahoo, Icahn School of Medicine at Mount Sinai
Exosomes in diagnostics and therapeutics in cardiovascular medicine
Joshua Hutcheson, Florida International University
Cardiovascular mechanics and extracellular vesicles

Cardiovascular Omics
Matthias Mann, Max Planck Institute of Biochemistry
Mass spectrometry-based proteomics and its applications in cardiovascular research
Sasha Singh, Brigham and Women’s Hospital, Harvard Med School
Moving beyond deep sequencing – exploring the prognostic and diagnostic potential of the plasma proteome

 

Special Symposia

 

Pre-Conference Meeting for Trainees

Organizers: Nicholas Chavkin, Yale University and Thanh Theresa Dinh, Stanford University
Sunday, October 14 - 1:00-5:00pm
Requires an additional registration fee of $25.

Program will consist of a guest speaker, a discussion or presentation on career development and abstracts presentations from graduate students and postdocs.

Refreshments will be served

*Session organizers will select the abstracts for presentation and the authors must be registered for this session.


Award Presentations and Lectures

Wednesday, October 17 - 2:00-4:00pm

Earl P. Benditt Award Lecture
Judah Folkman Award in Vascular Biology Lecture
Springer Junior Investigator Award Lecture

Recipients have not yet been determined


Bioinformatics Bootcamp: Informatics in Disease Biology and Drug Discovery
Tuesday, October 16 - 4:30-6:00pm
 
Hands-on worskhop to access, visualize and analyse IDG-specific data
  -- requires additional registration fee and there will be a limited number of attendees

Joint Sessions:

Signaling in Vascular Inflammation
Thursday, October 18 - 8:30am-12:00pm

Timothy Hla, Boston Children’s Hospital, Harvard Medical School
Novel approaches to control vascular inflammation with S1P-based therapeutics
Matthias Nahrendorf, Massachusetts General Hospital, Harvard Medical School
Myeloid cells in ischemic heart disease
Paul S. Frenette, Albert Einstein College of Medicine
Arterial and sinusoid endothelial cells in the hematopoietic stem cell niche
Catherine Carlynn Hedrick, La Jolla Institute for Allergy & Immunology
Monocyte function in the tumor microenvironment

Resolution of Inflammation
Organizers: Jennifer Allport-Anderson, Novartis and Ira Tabas, Columbia University
Tuesday, October 16 - 2:00-4:00pm

Gabrielle Fredman, Albany Medical College
Specialized pro-resolving mediators in atherosclerosis
Filip Swirksi, Massachusetts General Hospital, Harvard Medical School
Unleashing inflammation in cardiovascular disease
Ira Tabas, Columbia University
Mechanisms of impaired inflammation resolution in atherosclerosis

Vascular Therapeutics
Organizers: Zorina Galis, NHLBI/NIH and Chris Vlahos, Eli Lilly and Co.

Zorina Galis, NHLBI/NIH
The NIH perspective: partnering to bring cardiovascular therapeutics from idea to market
Chris Vlahos, Eli Lilly and Co.
Bringing your discoveries to market: strategies and solutions to partnering with industry
Peter Libby, Brigham and Women’s Hospital, Harvard Medical School
The academic perspective: from bench discovery to clinical trials
Tudor Oprea, University of New Mexico
The bioinformatics perspective: drug discovery in the age of big data

Registration and abstract submission will open in January 2018