Genetics and Genomics of Vascular Disease Workshop
September 13-16, 2009
Hyannis, MA

Preliminary Program

Sunday September 13^th                

7:00 PM           Welcome

7:15 PM           Keynote Address – Marfan Disease and Related Disorders:  From Molecules to Medicines

                                    Hal C. Dietz, Howard Hughes Medical Institute, Johns Hopkins School of Medicine

8:00 PM                        Reception

Monday September 14^th

7:00 AM - 8:30 AM                Breakfast on site

Hemangiomas  

8:30                 Hemangioma pathogenesis

                                    Bjorn Olsen, Harvard Medical School

9:00                 Vasculogenesis from hemangioma-derived multipotent stem cells

                                    Joyce Bischoff, Children’s Hospital Boston

9:30 – 10:00    Two short talks from submitted abstracts

10:00 - 10:30 AM                   Coffee Break

New Signaling Paradigms in Vascular Malformation

10:30               Pathogenesis of vascular malformations

                                    Miikka Vikkula, de Duve Institute, UCL

11:00               HEG-CCM signaling in vascular development and disease

                                    Mark L. Kahn, University of Pennsylvania

11:30-12:00     Two short talks from submitted abstracts

12:00 PM -1:30 PM                Lunch on site

Pathogenesis of Arteriovenous Malformation

1:30                 Notch signaling in arterial venous hierarchy and arteriovenous malformation

                                    Rong A. Wang, University of California, San Francisco

2:00                 Hereditary hemorrhagic telangiectasia and arteriovenous malformation

                                    S. Paul Oh, University of Florida, Gainesville

2:30 – 3:00      Two short talks from submitted abstracts

3:00 PM - 3:30 PM                Coffee Break

Forward and Reverse Genetic Studies of Vascular Disorders

3:30                 Identification of intracranial aneurysm susceptibility loci using whole genome association

                                    Murat Günel, Yale University

4:00                 Dissecting CADASIL pathophysiology using mouse models

                                    Anne Joutel, INSERM

4:30 – 5:00      Two short talks from submitted abstracts

Dinner on your own

7:30                 Special Lecture: Endothelial microRNAs and postnatal angiogenesis

                                    William C. Sessa, Yale University

8:00 PM - 10:00 PM                Poster Session 1

Tuesday September 15^th

7:00 AM – 8:30 AM                Breakfast on site

Genetic Determinants of Ischemic Disease

8:30                 Genetic control of cerebral infarction

                                    Douglas A. Marchuk, Duke University

9:00                 Genetic basis of collateral circulatory insufficiency

                                    James E. Faber, University of North Carolina, Chapel Hill

9:30 – 10:00    Two short talks from submitted abstracts

10:00-10:30 AM                   Coffee Break

Genetic Determinants of Vascular Response 

10:30               Genetic mechanisms of vascular remodeling induced by low blood flow

                                    Vyacheslav A. Korshunov, University of Rochester

11:00               Mapping the genetic determinants of microvasculature angiogenesis in mice

                                    Bruce Herron, Wadsworth Institute

11:30-12:00     Two short talks from submitted abstracts

12:00 PM – 1:30 PM                Lunch on site

Vascular Disease in Metabolic Syndrome - Human Genetic/Genomic Studies

1:30                 Genetic risk factors for Diabetes – A ‘cardiovascular disease-equivalent’

                                    Markku Laakso, University of Kuopio, Finland

2:00                 Linkage studies of Coronary Artery Disease – Role of lipid metabolism genes

                                    Svati Shah, Duke University

2:30-3:00         Two short talks from submitted abstracts

3:00 PM – 3:30 PM                Coffee Break

Vascular Disease in Metabolic Syndrome - Rodent Genetic/Genomic Studies

3:30                 Progress and prospects in rat genetics to study vascular disease

            Timothy J. Aitman, Imperial College, London

4:00                 Genetic determinants of hypertension in the spontaneously hypertensive rat

                                    TBD

4:30-5:00         Two short talks from submitted abstracts

Dinner on your own

8:00 PM – 10:00 PM                Poster Session 2

Wednesday September 16^th

7:00 AM – 8:30 AM                Breakfast on site

Atherosclerosis and Coronary Artery Disease – Human Genetic/Genomic Studies

8:30                 Genetic determinants of coronary artery disease

                                    Ruth McPherson, University of Ottawa, Canada

9:00                 Gene-environment interaction and oxidative stress in coronary artery disease

                                    TBD

9:30-10:00       Two short talks from submitted abstracts

10:00-10:30 AM                   Coffee Break

Atherosclerosis and Coronary Artery Disease – Mouse Genetic/Genomic Studies

10:30               Whole-genome expression profiling of multiple organs in coronary artery disease: 

                        A systems approach

                                    Johan Björkegren, Karolinska Institute,  Stockholm, Sweden

11:00               The role of the CD40/TRAF6 axis in neointima formation and arterial remodeling

            Esther Lutgens, University of Maastricht, The Netherlands

11:30-12:00     Two short talks from submitted abstracts

12:00 PM                         Closing Remarks