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NHLBI Outstanding Investigator Award (R35)

The purpose of the NHLBI Outstanding Investigator Award (OIA) is to promote scientific productivity and innovation by providing long-term support and increased flexibility to experienced Program Directors (PDs)/Principal Investigators (PDs/PIs) who are currently PDs/PIs on at least two NHLBI R01-equivalent awards and whose outstanding record of research demonstrate their ability to make major contributions to heart, lung, blood and sleep (HLBS) research. The NHLBI OIA is intended to support a research program, rather than a research project, by providing the primary and most likely sole source of NHLBI funding on individual grant awards. The NHLBI OIA will support the research program of NHLBI-funded investigators for up to seven years. The NHLBI OIA will provide investigators increased freedom to conduct research that breaks new ground or extends previous discoveries in new directions. It will also allow PDs/PIs to take greater risks and to pursue research that requires a longer timeframe. Research supported by the NHLBI OIA should be within the scope of the NHLBI mission (http://www.nhlbi.nih.gov/about/org/mission), sleep disorders closely-coupled to HLB outcomes, or basic sleep and circadian regulation.

It is anticipated that the NHLBI OIA will:

•Provide a stable funding environment, thereby improving productivity and facilitating ambitious, creative research;

•Increase scientific innovation by enabling flexibility in pursuing new research directions as they arise, since PDs/PIs will not be bound to specific aims proposed in advance of the studies;

•Reduce the time researchers spend writing grant applications and managing multiple grant awards, thereby allowing more time to be devoted to conducting research;

•Facilitate PDs/PIs commitment to research through increased stability of funding; and

•Enable PDs/PIs to devote more time and energy to mentoring junior scientists and providing scientific service.


Eligibility to apply through this FOA is limited to PDs/PIs who meet all of the following criteria:

•Are currently PD/PI on at least two NHLBI R01-equivalent (defined here as R01, R37, DP1, or DP2) awards;

•Have received continuous R01-equivalent support from the NHLBI for at least the past four years as a PD/PI; and

•Can commit a minimum of 50% research effort (i.e., minimum of six calendar months) throughout the duration of the NHLBI OIA. Investigators receiving NHLBI OIAs must relinquish their other NHLBI research grants, with a limited number of exceptions as outlined in Part 2, Section I.


More information at http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-16-024.html