2014 NAVBO Judah Folkman Award in Vascular Biology -
Tatiana V. Byzova, Cleveland Clinic
Dr. Byzova will give her talk, "Mechanisms of cellular integration in vasculature," on October 22 at Vascular Biology 2014 in Pacific Grove, CA (on the Monterey Peninsula).
The NAVBO Meritorious Awards Committee and Council announce with pleasure the selection of Tatiana Byzova, Ph.D., as the recipient of the 2014 Judah Folkman Award in Vascular Biology. This award recognizes outstanding contributions from vascular biologists who are at a mid-career level (within fifteen years of their first faculty appointment). Dr. Byzova is Vice-Chair, Department of Molecular Cardiology, and the Robert Canova Endowed Chair in Angiogenesis Research in the Lerner Research Institute at the Cleveland Clinic. She will present the Judah Folkman Award Lecture during Vascular Biology 2014 in Pacific Grove, California, on October 22, 2014.
Dr. Byzova received her Ph.D. in Cell Biology in 1995 at the Institute of Experimental Cardiology, National Cardiology Research Center, Moscow, Russia. In 1996, she began post-doctoral studies in the laboratory of Dr. Edward F. Plow in Molecular Cardiology, Center for Thrombosis and Vascular Biology at Lerner. There she has remained to the present, rising in 2008 to the position of Staff (Full Professor equivalent) in the Departments of Molecular Cardiology and Cardiovascular Medicine and the Taussig Cancer Center.
Tatiana Byzova has made major contributions to our understanding of vascular biology and mechanisms of angiogenesis. Particularly noteworthy are her studies showing that: crosstalk between VEGF/VEGFR and integrins depends on their formation of a physical complex, that phosphorylation regulates this interaction, and that this complex determines their collective ability to regulate angiogenesis in vivo. In addition, the work of her lab has indicated that different isoforms of Akt activate cell-specific signaling pathways in distinct cell types, including those leading to an angiogenic response of endothelial cells.
In other studies, her lab has showed that the molecular pattern of end products of lipid oxidation, generated during inflammation, is recognized by TLR2 on endothelial cells. This interaction leads to VEGF-independent angiogenesis, a previously unrecognized pathway of angiogenesis. Thus, she established that, along with pathogen- and danger- associated molecular patterns, TLRs sense and respond to oxidation-associated molecular patterns, and TLRs can trigger the responses of endothelial cells to support angiogenesis in vivo. These paradigm-shifting studies have been broadly publicized and are likely to define new directions in angiogenesis research for many years to come. Her research, in the words of one of her nominators, "...epitomizes the spirit of Dr. Folkman."
In addition to attending to her own research interests, Dr. Byzova has generously served her fellow vascular biologists as a Councilor to NAVBO, helped to organize Vasculata in Cleveland, and is the NAVBO liaison to the ATVB Council of the AHA. Please join us at Asilomar for Vascular Biology 2014 to recognize Dr. Byzova's contributions to our field.
Compiled by William R. Huckle,