Members’ Labs

Miranda Good Ph.D.

Assistant Professor
Molecular Cardiology Research Institute
Tufts University School of Medicine

Description of primary research:
The overall objective of the Good Lab is to understand the mechanisms that regulate blood vessel function and inflammation and contribute to the etiology of neurological diseases. We have recently found that endothelial Panx1 regulates cerebral arterial myogenic tone and venous inflammation, which are both dysregulated in ischemic stroke and Alzheimer’s Disease. We take an interdisciplinary approach encompassing fundamental molecular and cellular biology, in vivo state-of-the-art imaging technologies, and in vivo pathophysiological models (mouse and human) to further our understanding of how blood flow regulation and inflammation contribute to the etiology of neurological diseases and to dissect the role of arterial and venous endothelial Panx1 in ischemic stroke and Alzheimer’s Disease.

Laboratory web site URL: https://www.tuftsmedicalcenter.org/physiciandirectory/miranda-good

Members of the Laboratory

Recent Publications

Recent Publications:

Good ME*, Young AP, Wolpe AG, Ma M, Hall PJ, Duffy CK, Aronovitz MJ, Martin GL, Blanton RM, Leitinger N, Johnstone SR, Wolf MJ, Isakson BE. (2021). Endothelial pannexin 1 regulates cardiac response to myocardial infarction. Circ Res. In Press
- * Corresponding Author.
Good ME, Eucker SA, Li J, Bacon HM, Lang SM, Butcher JT, Johnson TJ, Gaykema RP, Patel MK, Zuo Z, Isakson BE. (2018). Endothelial cell Pannexin1 modulates severity of ischemic stroke by regulating cerebral inflammation and myogenic tone. JCI Insight. 3(6). PMID: 29563335 PMCID: PMC5926909.
Good ME*, Chiu YH*, Poon IKH*, Medina C, Butcher JT, Mendu SK, DeLalio LJ, Lohman AW, Leitinger N, Barrett E, Lorenz UM, Desai BN, Jaffe IZ, Bayliss DA, Isakson BE#, Ravichandran KS#. (2018). Pannexin 1 channels as an unexpected new target of the anti-hypertensive drug spironolactone. Circ Res. 122(4): 606-615. PMID: 29237722 PMCID: PMC5815904.
- * Co-First Authors; # Co-Corresponding Authors.