Members’ Labs

Yanbo Fan, PhD

Assistant Professor
Department of Cancer Biology
University of Cincinnati College of Medicine

Description of primary research:
Our lab has major research interests in vascular biology, metabolism, and the intersection of vascular disease and cancer. We currently focus on elucidating molecular mechanisms underlying vascular diseases, including atherosclerosis and aortic aneurysms, diabetes-associated vascular complications, and tumor angiogenesis. One of the important directions in our lab is the role of transcription factor EB, a master regulator of autophagy and lysosomal biogenesis, in vascular diseases and tumor vascular networks. We use molecular, cellular, genomic, and mouse genetic (conditional knockout, transgenic and mutant knock-in) approaches for the studies and translational research.

Laboratory web site URL:
https://med.uc.edu/depart/cancer-biology/labs/fan-laboratory

Members of the Laboratory

Recent Publications

Ren L*, Du W*, Song D, Lu H, Hamblin MH, Wang C, Du C, Fan GC, Becker RC, Fan Y. Genetic ablation of diabetes-associated gene Ccdc92 reduces obesity and insulin resistance in mice. iScience. In press, Published: December 07, 2022. DOI: https://doi.org/10.1016/j.isci.2022.105769.
Liang W, Lu H, Sun J, Zhao G, Wang H, Guo Y, Eitzman D, Chen YE, Fan Y#, Zhang J. KLF11 Protects against Venous Thrombosis via Suppressing Tissue Factor Expression. Thromb Haemost. 2022 May;122(5):777-788. PMID: 344288344.
Sun J, Lu H, Liang W, Zhao G, Ren L, Hu D, Chang Z, Liu Y, Garcia-Barrio MT, Zhang J, Chen YE, Fan Y. Endothelial TFEB (Transcription Factor EB) Improves Glucose Tolerance via Upregulation of IRS (Insulin Receptor Substrate) 1 and IRS2. Arterioscler Thromb Vasc Biol. 2021;41(2):783-795. PMID: 33297755.
Lu H, Sun J, Liang W, Chang Z, Rom O, Zhao Y, Zhao G, Xiong W, Wang H, Zhu T, Guo Y, Chang L, Garcia-Barrio MT, Zhang J, Chen YE, Fan Y. Cyclodextrin Prevents Abdominal Aortic Aneurysm via Activation of Vascular Smooth Muscle Cell TFEB. Circulation. 2020;142(5):483-498.2020. PMID: 32354235
Liang W, Fan Y*, #, Lu H, Chang Z, Hu W, Sun J, Wang H, Zhu T, Wang J, Adili R, Garcia-Barrio MT, Holinstat M, Eitzman D, Zhang J, Chen YE.Lu H, Hu W, Chang Z, Zhang J, Chen YE. Krüppel-like Factor 11 inhibits arterial thrombosis via Inhibiting tissue factor in the vascular wall. Arterioscler Thromb Vasc Biol. 2019;39(3):402-412. PMID: 30602303. Editorially commented in ATVB.
Fan Y#, Lu H, Liang W, Guo Y, Zhang J, Zhu T, Hao Y, Yin KJ, Garcia-Barrio MT, Zhang J, Chen YE. Endothelial TFEB regulates post-ischemic angiogenesis via AMPK-alpha activation. Circ Res, 2018 March 30; 122(7):945-957. PMID: 29467198.