Members’ Labs

Xiaolei Liu, PhD

Assistant Professor
Lemole Center for Integrated Lymphatics Research
Department of Cardiovascular Sciences
Lewis Katz School of Medicine
Temple University

Primary Research:

The Liu lab research studies lymphatic vessels during development and cardiovascular diseases. We study molecular mechanisms and signal cues that guides early lymphatic vessel formation and development. In parallel, we have a strong focus to understand lymphatic functions in cardiovascular diseases, particularly ischemic cardiac diseases. We seek to identify previous unknown developmental pathways and use them for the treatment of lymphatic related disorders/diseases.

Gaseous transmitters (e.g. carbon monoxide / carbon monoxide releasing molecules; CORMs) are investigated as potential modulators/therapy of systemic inflammation.

Laboratory web site URL:

https://www.theliuteam.com

Recent Presentations (Invited):

2023 AHA scientific Sessions, Philadelphia, Nov 10-13
GRC angiogenesis, Rhode Island, July 31-Aug 4
NIH virtual workshop, “Yet to be charted: Lymphatic system in health and disease”, Sept 19-20, 2022
2022 AHA Scientific Sessions, Chicago, Nov 11-13, 202

Members of the Laboratory

Recent Publications

https://www.ncbi.nlm.nih.gov/myncbi/xiaolei.liu.2/bibliography/public/

Liu X, Oliver G. The Lymphatic Vasculature in Cardiac Development and Ischemic Heart Disease. Circ Res. 2023 Apr 28;132(9):1246-1253.
Liu X, Cui K, Wu H, Li KS, Peng Q, Wang D, Cowan DB, Dixon JB, Sathish Srinivasan R, Bielenberg DR, Chen K, Wang DZ, Chen Y, Chen H. Promoting Lymphangiogenesis and Lymphatic Growth and Remodeling to Treat Cardiovascular and Metabolic Diseases. Arterioscler Thromb Vasc Biol. 2023 Jan;43(1):e1-e10.
Liu X, De la Cruz E, Gu X, Balint L, Oxendine-Burns M, Terrones T, Ma W, Kuo H, Lantz C, Bansal T, Thorp E, Burridge P, Jakus Z, Herz J, Cleaver O, Torres M and Oliver G. Lymphoangiocrine signals promote cardiac growth and repair. Nature. 2020 Dec;588(7839):705-711.
Glinton K, Ma W, Lantz C, Grigoryeva L, DeBerge M, Liu X, Febbraio M, Kahn M, Oliver G, Edward B Thorp E. Macrophage-produced VEGFC is induced by efferocytosis to ameliorate cardiac injury and inflammation. J Clin Invest. 2022 Mar 10;e140685.
MA W, Gil HJ, Liu X, Diebold PL, Morgan MA, Oxendine-Burns M, Gao P, Chandel NS, Oliver G. Mitochondrial respiration controls the Prox1-Vegfr3 feedback loop during lymphatic endothelial cell specification and maintenance. Sci Adv. 2021 Apr 30;7(18):eabe7359.
Lioux G, Liu X, Temiño S, Oxendine M, Ortega S, Kelly R, Oliver G and Torres M. A Second Heart Field-derived vasculogenic niche contributes to cardiac lymphatics. Dev Cell. 2020 Feb 10;52(3):350-363.e6.
Dong Y, Lee Y, Cui K, He M, Wang B, Bhattacharjee S, Zhu B, Yago T, Zhang K, Deng L, Ouyang K, Wen A, Cowan DB, Song K, Yu L, Brophy ML, Liu X, Wylie-Sears J, Wu H, Wong S, Cui G, Kawashima Y, Matsumoto H, Kodera Y, Wojcikiewicz RJH, Srivastava S, Bischoff J, Wang DZ, Ley K, Chen H. Epsin-mediated degradation of IP3R1 fuels atherosclerosis. Nat Commun. 2020 Aug 7;11(1):3984.
Gur-Cohen S, Yang H, Baksh SC, Miao Y, Levorse J, Kataru RP, Liu X, de la Cruz-Racelis J, Mehrara BJ, Fuchs E. Stem cell-driven lymphatic remodeling coordinates tissue regeneration. Science. 2019 Oct 31. pii: eaay4509.