Members’ Labs

Tirthadipa Pradhan-Sundd, PhD

Assistant ProfessorVascular Medicine Institute
Department of Medicine
University of Pittsburgh School of Medicine.

Description of primary research:
We love to learn about hematological diseases. Our primary disease model is sickle cell disease. Using state-of-the art imaging, molecular biology and biochemical techniques we sought to understand the effect of hemolysis and heme/iron accumulation in sickle cell disease associated liver injury and the role of vascular components (endothelial and Kupffer cells) in these processes. Our second love is Hemophilia. We are trying to understand the role of sinusoidal endothelial cells in liver directed gene transfer in Hemophilia. A more recent continuously growing interest is to understand the mechanism of erythorophagocytosis in different hematological disease models.

Laboratory web site URL:
https://www.pradhansunddlab.com/

Members of the Laboratory

Recent Publications

Pradhan-Sundd T, Kato GJ, Novelli EM. Molecular Mechanisms of Hepatic Dysfunction in Sickle Cell Disease: Lessons from The Townes Mouse Model. Am J Physiol Cell Physiol. 2022 Jun 27. Online ahead of print. PMID: 35759437 Review Article. Cover Image.
Vats R, Kaminski TW, Brzoska T, Leech JA, Tutuncuoglu E, Katoch O, Jonassaint JC, Tejero J, Novelli EM, Pradhan-Sundd T, Gladwin MT, Sundd P. Liver to lung microembolic NETs promote Gasdermin-D-dependent inflammatory lung injury in Sickle Cell Disease. 2022 Jun 23:blood.2021014552. Online ahead of print. PMID: 35737916. Cover Image.
Kaminski TW, Ju E-M, Gudapati S, Vats R, Arshad S, Dubey RK, Katoch O, Tutuncuoglu E, Frank J, Brzoska T. Stolz DB, Watkins SC, Chan SY, Ragni MV, Novelli EM, Sundd P, Pradhan-Sundd T. Defenestrated endothelium delays liver directed gene transfer in Hemophilia A mice. Blood Adv. 2022 Jun 28;6(12):3729-3734. PMID:35427414.
Vats R, Kaminski T, Ju E-M, Brozska T, Tutuncuoglu E, Tejero J, Novelli E, Sundd P, Pradhan-Sundd T. P-selectin deficiency promotes liver senescence in sickle cell disease mice. 2021; Feb 22; PMID: 33619560. Cover Image; Selected for Editorial.