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Lessons Learned

Lessons Learned

The NAVBO Education Committee has asked some junior faculty to share their experiences during the transition from trainee to first independent post. We hope that their accounts of challenges confronted, dilemmas dissected, and lessons learned will help smooth your career path.

Stefania Nicoli, Yale School of Medicine


The View from the Other Side of the Desk
by Stefania Nicoli, Yale University School of Medicine

Nicoli2016LessonsMy name is Stefania Nicoli, and I have been an Assistant Professor at the Yale Cardiovascular Research Center since 2012. This four-year journey in the academic world, more than any previous experience, has made me understand the importance of mentoring models for junior faculty.

Reaching the other side of the desk is what everybody dreams of during their training positions. However, during this time you are not only learning to become a boss but also a mentor. You are now in charge of efficiently communicating, motivating your employees, solving team conflicts, understanding and working with their career and life priorities, their weaknesses and reactions to stress and rejection, and ultimately, their success. Indeed, it appears that this part of the work is energy consuming and sometimes no matter what you might say or do you are wrong and for many of us this feeling, together with the continuous stress of reaching scientific excellence, is overwhelming.

Becoming a boss might be a natural process for a new faculty member, as we ourselves reached this academic status thanks to determination, self-assurance and hard work, traits typical of a leader. However, becoming a mentor is not necessarily included in our natural predispositions. Seeking direction, I asked several senior colleagues about their experiences regarding how they became mentors. Interestingly, there are various theories, all very personal, that I would like to classify into two distinct points of view: the Darwinian or Lamarckian theory of the junior faculty evolution. Essentially some faculty members believe in "natural selection" of the strongest phenotype. Others believe in the progressive learning process of more complex skills that allow successful "adaptation and survival" in any environment.

Of course, this sounds like a scientific joke, but there is some truth in both theories. Indeed, in our competitive and difficult economic climate, scientists have limited time to learn naturally from their mistakes. Therefore, learning quickly is the key to successfully "survive" and "drive." I found it crucial having someone to teach us mentoring strategies as rapidly as possible, to avoid energy dispersion while also gaining efficiency. For example, attending periodic psychology workshops or leadership courses is essential in acquiring these tools. High profile corporations invest time and considerable resources understanding strategies to make employees more efficient. Obviously, academia might not have the same capacity, but an investment toward junior faculty mentoring programs is, in the long run, important for the success of the entire institution.

Published April 14 - NAVBO NewsBEAT

Sathish Srinivasan, Oklahoma Medical Research Foundation


Identifying the important questions
by Sathish Srinivasan, Oklahoma Medical Research Foundation

S SrinivasanMy name is Sathish Srinivasan, and I am an Assistant Member at Oklahoma Medical Research Foundation (OMRF), located in the vibrant downtown area of Oklahoma City. I came to OMRF in February of 2013 after an enjoyable period of postdoctoral training in the lab of Dr. Guillermo Oliver at St. Jude Children’s Research Hospital, Memphis. The last three years have been the most challenging of my entire life. Identifying the important questions, addressing those questions with innovative approaches, and being a motivating leader and spokesman for your team are very difficult tasks. Knowing that there is no guarantee for success makes each task all the more challenging. Here I will list a few things that I think are important for a startup lab. I hope that my experience will be helpful to others who are taking their first steps as independent investigators.

Getting the team together: As a new PI, it can be difficult to attract talented, motivated, and experienced researchers to join your team. However, setting the bar high is important both for the team and for the individual. I am very fortunate to have Xin Geng (staff scientist), Boksik Cha (post doc), and Lijuan Chen (research assistant) in my lab. They are my super heroes. Stephanie Yeager (research assistant) and Bing Liao (post doc) also made important contributions during their stay in the lab.

Plan to continue working in the lab: You will likely be the one with the most experience in your field when starting the lab. Be ready to continue working in the lab and training others. The time invested will pay off. Riaj Mahamud (graduate student), who joined my lab with little experience but with a strong motivation, is now a well-trained, important member of my lab.

Don’t hesitate to invest in your startup: Proper reagents and tools are a must to run your lab, so don’t be stingy in making that mouse model or buying that microscope. But do get a quote and make sure you will get good service.

Be generous: You got hired because other PIs in the institution thought that they could collaborate with you; be willing to share your expertise and resources to help others both within and outside of the institution. The favor will be returned to you many times over.

Choose your collaborators carefully: I am lucky to have many thoughtful collaborators. However, collaborator-on-collaborator conflict is not uncommon and could be career-ending. Make sure you are truly independent in collaborative projects. Also, verify the sincerity of a collaboration request. You don’t want your precious time and energy to be wasted on projects that the collaborators are not serious about.

Focus: When I started the lab, I wanted to simultaneously work on 10 different projects and write five R01 applications. It was an exercise in futility. Focus on the most important questions that you can address with your expertise and resources and for which you are recognized. Try to obtain small grant funding that will keep your lab moving forward. Bigger grants, such as an NIH R01 grant, need plenty of time and work before applying. The time you spend on writing those big grants can be better spent in generating the preliminary data and publications that are absolutely important in getting those larger grants funded.

Be cautious…: In this highly competitive research environment, it is important to find a balance between camaraderie and caution. Avoid presenting unpublished data until you get some traction.

…but don’t get cynical: Many papers and grants do get favorably reviewed due to the political connections of the PIs. Yours may seem to be unfairly reviewed. You will be angry and discouraged, but acknowledge the reality and your emotions and move on. Grow a thick skin, keep improving, and believe that good science will be appreciated and acknowledged sooner or later. I am fortunate to have known plenty of researchers who are genuinely curious about nature, passionate about research and kind-hearted to support others.

Improve your writing skills: It is important to have good science. It is even more important to communicate your work well. My first two R01 applications were beaten down, and rightfully so. Now my grantsmanship is a work in progress. Do everything possible to make your grants and papers easy to read and understand. Your peers deserve that respect.

Try to relax: If we are lucky, we are expected to be creative and productive for 30-40 years. It is a daunting task. When I confided my fear to Mike Davis (University of Missouri, Columbia), he gave me the best career advice that I ever got. If you are worried about everything, you are not going to do anything. Andrew McMahon likens the scientific career to running a marathon. You have to plan for the next 3-5 miles (years) and not focus on the finish line. So find your circle of supporters, spend quality time with your family, develop a hobby, read good literature and give a good fight. It ain’t over ‘til it’s over.

Published June 9, 2016 - NAVBO NewsBEAT

Daniela Simona Ardelean, University of Western Ontario


Remember why you are doing science
by Daniela Simona Ardelean, University of Western Ontario

Do you remember the day when you thought that science is really cool and that this is what you want to do, no matter what? For some, it was a defined moment; for others, a longer, slow process. Some people could explain it, others just knew it. But for all, the knowledge or feeling (yes, it can be either one) that doing science is the right thing, was the same. You just knew. Remember that when you come across challenges that may seem insurmountable.

I am a pediatric rheumatologist who is doing translational research. Since I have started one year ago as a junior faculty at the Schulich School of Medicine and Dentistry at University of Western Ontario in London, Ontario, Canada, I have been working towards establishing my lab and building the team. This is still work in progress.

The transition from trainee to faculty is often lengthy and difficult. On this journey, I have learned a few things that I would like to share with you:

Think early about your research program. Beyond research projects, you also need to discuss about your research program with your future collaborators, mentors and funding agencies.

What is your long-term goal? What is your vision? What do you need to get you there? It is important to define it early.

Connect with peers and scientists outside your discipline. To broaden your knowledge and to find collaborators and potential mentors, it is important to attend meetings, seminars, workshops, etc., in other disciplines.

Find out what funding opportunities are available at your institution(s). The University, affiliated Research Institutes, the Department(s) where you are appointed or cross-appointed, hospital Foundations, etc., may have their own funding and internal competitions. Find out early about these opportunities and apply to them.

We need time for reflection. We are all busy people. However, without time put aside regularly for reflection, for thinking things through and for a break, it is difficult to come up with that great idea that is worth pursuing, be creative, have balance in life, and evolve as a human being.

Writing is about telling stories that matter to you and others. There was something that motivated you in the first place to look for answers when there were very few or none. Findings how things work, deciphering the mechanisms of a process or disease, discovering new treatments for your patients. Conveying that "something" in writing increases the chance that your grant application or paper will connect with those that read it.

Despite the long path, challenges, ups and downs, we are privileged to do research. Remember why you chose science and make the most of your journey.

Published September 29, 2016 - NAVBO NewsBEAT

Mete Civelek, University of Virginia


Lessons Learned
by Mete Civelek, University of Virginia


I started my laboratory at the Center for Public Health Genomics at the University of Virginia about two years ago. I made several good decisions as well as several mistakes during this time. While everyone’s experiences will be different, I would like to share some of the lessons I learned with the hope that you will make wiser choices when you start your research group.

I immediately found a group of likeminded junior PIs who also started their labs around the same time as me at UVA. This group has been a great support both mentally and scientifically. In fact, four of us hold joint lab meetings together as we have overlapping interests. If you are just starting your lab, I highly recommend to you to be part of the New PI Slack, which is a community of about 400 junior faculty members primarily across the United States (https://newpislack.wordpress.com/). This is a group of generous and thoughtful new PIs who share many things from examples of grant applications to advice for wet lab and computational tools, funding opportunities, how to deal with diversity-related issues, and even tips for work-life balance.

One of the mistakes I made was not to have a laser-like focus on a single project that will result in a publication as soon as possible. Since publications measure our productivity, it is important for a junior PI to prove that he/she can produce results as a result of all the investment an institution makes. My advice is to focus on a publication rather than grant applications in the first one or two years. If you are going to send in grant applications, it is better to apply to organizations that provide feedback so that you can improve your application by addressing the reviewers’ comments and resubmit.portrait civelek mete 2015 09 11

Hiring and managing people will prove to be challenging. You will not find a postdoctoral fellow or a graduate student who will be just like you. Many times, you will think “I could have done this in an hour instead of a day.” I learned to be patient as I trained the lab members and allowed them to make mistakes. It is the only way the trainees are going to master the techniques. I also learned to look out for warning signs as it is important to correct the mistakes quickly so that they don’t accumulate and become bigger problems in the future. I quickly learned that weekly one-on-one meetings where we go over even small details increased the productivity of the lab.

I am required to teach as part of my appointment. I started a new class in large-scale data analysis, and it took a considerable amount of my time in the first year. Becoming a good teacher is an iterative process, and it takes time to be a good teacher. If you have teaching duties, set aside only one day of the week to prepare for the class. We all tend to have perfectionist qualities, but you do not want teaching to consume your precious time.

Finally, science is a collective effort. Your lab will be more productive if you can create a welcoming and fun environment in the lab where diverse ideas are openly discussed.

Published September 14, 2017 - NAVBO NewsBEAT

Michael Dellinger, UT Southwestern Medical Center


by Michael Dellinger, UT Southwestern Medical Center

Dellinger PicWEBMusic has always been an important part of my life. I enjoy listening to songs and trying to find the message in lyrics. When I started my lab in 2014, I was the only person in the lab for approximately two months. This was a chance for me to play my favorite albums in the lab, and I listened to “Ill Communication” by the Beastie Boys at least once every other day. As people joined my group, I discovered that I had ill communication. Sometimes I had a hard time getting my ideas across to the people in my lab. Below are a few suggestions that have helped me become a better communicator and a more efficient and effective leader. 

Tailor your interactions with the members of your lab to suit their specific needs. Your lab is going to be filled with people with different backgrounds and levels of experience. Take the time to have individual meetings with the members of your lab. Over time you will discover who in your group finds verbal instructions useful and who in your group finds a combination of verbal and written instructions beneficial. Taking this time will ensure that you and the members of your lab are on the same page and that projects move in the right direction. 

Listen to the people in your lab. Yogi Berra said, “You can observe a lot by just watching.” You can also hear a lot by just listening. Sometimes you will hear bad news. If a person in your lab tells you that there is a specific problem, take action. Other times, you will hear excitement over a new result. Listening to what the people in your lab say will help you customize your interactions with them. It is also a lot of fun learning about the people who are spending their days (and nights) working hard in your lab.

Regularly review lab notebooks. One way the people in your lab communicate with you is through their lab notebooks. This form of communication is critical, especially when the people are no longer in your lab. It is essential that you can easily find descriptions and details of experiments. Take a little time each week to really read lab notebooks and make sure that you understand what is written.  

Take a course on grant writing. I took a course on grant writing during my first year at UT Southwestern. It was one of the best courses I have ever taken and I regularly refer to the materials I received as part of the course. If you have a chance, take a course on grant writing. This will help you communicate your ideas in a coherent manner in grants and papers. I’ve also been able to join a group at UT Southwestern that meets regularly to discuss grants. This has helped me become a better writer and reviewer.

Contact and interact with foundations and societies. In addition to being a member of the faculty of UT Southwestern, I am also the director of research of the Lymphatic Malformation Institute (www.lmiresearch.org) and I regularly interact with the Lymphangiomatosis & Gorham’s Disease Alliance (www.lgdalliance.org). I have found that foundations and societies are always looking for help to carry out their respective missions. Reach out to foundations and societies that are relevant to your area of research. Let these people know who you are and offer your assistance. This could lead to opportunities to speak to the patient community and other rewarding experiences.  

It can take time to become an effective communicator. But by putting the time in to hone your communication skills, you will find it easier to realize your ideas, lead your group, and inspire the next generation of scientists in your lab.

Published November 2, 2017 - NAVBO NewsBEAT

Henar Cuervo, University of Illinois at Chicago


Lessons Learned
by Henar Cuervo, University of Illinois at Chicago

Cuervo Grajal 2I started my lab at the University of Illinois at Chicago (UIC) about a year and a half ago. I am still finding my way through and know that there are many challenges ahead, but I am happy to share some of my lessons learned. Some of you may find it helpful; some of you may enjoy the trip down memory lane.

Get plenty of advice, and then trust that you are making the best decision you can. As scientists, we do a thorough background research before we start an experiment, we search what has been published, what techniques have been used, and then once we have all the information, we design and execute our experiment. So, I felt that I needed to do the same when making important decisions about managing/setting up my new lab. I read several books (I strongly recommend “At the Helm: Leading your laboratory” by Kathy Barker, and “Making the Right Moves” published by the HHMI), and took advantage of the great faculty mentorship at UIC. However, more frequently than not, I would hear opposing advice from similarly successful senior professors; for example: Professor A would suggest using your Start-up funds aggressively to get the best preliminary data you could to secure grant funding, while Professor B would recommend to be cautious with spending and save some of the Start-up funds for a rainy day. As it usually happens in life, nothing is black and white, and everyone has had a different story and has different circumstances, ultimately the decision has to work for you and how you like to manage your lab.

Learn to say no. This is one of the big clichés, I know, but after a year and a half I am still struggling with it. It is much easier said that done. As you start your lab you will be invited to give talks, to review papers, to review grants, to serve in multiple committees, to teach…etc. I actually find most of these activities to be exciting; they make me feel proud to be contributing to my Department/University, and to the overall scientific community—plus it is a good way to learn the lay of the land. I found that being part of the “Graduate Education Committee” in my Department allowed me, for example, to get familiar with the graduate student selection, and the thesis (and qualifying exam) rules and requirements. This experience turned out to be particularly useful when I was part of a qualifying exam committee, or when recruiting graduate students to my lab. Similarly, being a grant reviewer for the Department of Defense and seeing how that process worked was a fantastic learning experience towards crafting my own grants. However, while all this service work can be edifying and rewarding, it takes a substantial amount of time and focus, and it is easy to neglect your own research group. It is therefore critical to keep a good balance between your own research and the service to the academic/scientific community. As I mentioned, I still have not found the perfect formula (I am not even sure it exists), but I try to select talks, reviews, and other tasks that I feel I can either learn from, or that can help in the development of my career.

Be patient. The first year while setting up the lab is usually not as productive as you would like it to be. You have to spend time negotiating prices with sales representatives, preparing IRB and IACUC protocols, training students…etc. The experiments that you thought were so easy and just took you a couple of hours to get done when you were working at the end of your postdoc might take much more for your newly trained student(s). I remember feeling frustrated with how slow things were moving in the first months: I knew it would take some time to get the lab up and running, but I also wanted to be productive and get good results as soon as possible. I had to be patient, and focus on building my lab and training my students thoroughly. It took more time than I wanted, sure, but now when I see my students’ data and presentations I know it was worth it.

Published January 11, 2018 - NAVBO NewsBEAT

Stryder Meadows, Tulane University


Lessons Learned
by Stryder Meadows, Tulane University

Meadows Head Shot 1 2

Greetings from New Orleans! My name is Stryder Meadows and I am an Assistant Professor at Tulane University. In 2014, I dove head first into the most challenging undertaking of my life. I uprooted my family and started my own research lab in a new state. Reflecting on the past 3 years, I would like to think I've had some professional successes while minimizing the hiccups along the way. I'm happy to have the opportunity to share my thoughts and opinions about my journey, and hope that my experiences prove useful to future independent investigators. We are all somewhat thrown into this position with no road map for establishing a thriving research program, so be proactive in seeking advice and stay ahead of the game.

Focus on the science: You already know this but it's important to keep in mind - science drives everything. So get in the lab and stay focused! If you're like myself, you will have a tendency to get interested and distracted by too many potential projects. Don't do this - work hard and place your energy on the most promising projects that will drive your lab. Make sure these projects differentiate yourself from your postdoc advisor. And don't be afraid to use your start up funds because you need the resources and man/woman power to build a solid body of work for that first big grant.

Getting funded: The obvious goal is to get big money grants, but don’t forget about all those smaller grants out there, including those from your own institute. Take advantage of grants that are designed for new investigators. Acquiring these grants will look good on your resume, help with the research finances, and give you additional writing practice for your first big grant. In terms of the obtaining your first big grant, my advice is to hold off until you have a good, solid body of work. It takes time to build a story, and very few new investigators are going to get that big grant unless they’ve built a story, started publishing, etc. Be sure to have your mentors and colleagues look at your grants. A common mistake of a new investigator is to try and put too much into that first R01. Established investigators have been through this process many times and will know how to keep your grant focused.

Setting up the lab: Don’t plan on getting to your job and being able to set up your lab uninterrupted. There are ALWAYS unexpected bumps along the way that can stall your progress. Your tenure clock usually starts on your hire date, so every day, month and experiment is valuable. Use that window of time before the job starts to be proactive in getting the lab set up. Immediately work on the IACUC protocols and transferring your mice (if you work with them). This process can take months and really delay your experiments. You can also order equipment, supplies and reagents before you get to your job. Be sure to take advantage of deals for new investigators that most companies offer. Hire someone to help; you can put out job ads and interview people before you arrive. You’ll be in much better shape the sooner you can get that first experiment started.

Make your presence felt: You are the most productive person in your lab, so get in the lab and start the experiments that are going to get you funding. Establish the culture and work ethic of your lab, and be diligent in your training of lab personnel. At some point you won’t be able to spend as much time in the lab and those people you trained will be setting an example and training future members of the lab. With that in mind….

Be picky when assembling your research team: Check every reference and try to meet lab technician and postdoc candidates in person. With rotating graduate students, be sure to be in the lab so that you can really assess their critical thinking, bench skills and interactions with lab personnel. Even if you’re desperate for a grad student, don’t bring them on board unless you’re confident they will be a good fit. I’ve turned down students even though I could have used the extra hands, and I know I’ve dodged a few bullets. If red flags pop up or something doesn’t feel right, trust your gut and move on. This is advice I’ve gotten from almost every established investigator, including several that have made this mistake.

Learn to wear multiple hats: You’re now the boss, which means you’re job description includes being a leader, mentor, manager and advisor. Sliding between these different roles can be quite difficult. Each of us is different so figure out what works for you. Stay on top of things and pay attention. Know where your money is going and learn how to budget, even if you have an administrative person that covers the finances. Be mindful of what’s going on in the lab and be sure to have open communication with your staff. Remember, not every person reacts the same way and has the same drive and passion as you. So choose your motivational tactics wisely.

Balancing research and teaching: This part is for junior faculty members like myself that are expected to teach throughout the year and simultaneously run a successful research program. This has been one of the most challenging aspects of the job. Remember, you’re competing with lots of other researchers that have minimal teaching requirements. I’ve heard different views on whether this is an advantage or disadvantage. My opinion: it’s an advantage salary wise (usually more hard money in your salary), but a disadvantage to your research program. So figure out how to balance the time and energy put into teaching versus research. Many times the biggest components for tenure are teaching/school service, publications and funding. I would suggest finding out how much each component is weighted for tenure, and use that as a way to help guide and balance your effort going forward.

Publishing is the name of the game: You already know that publishing your work is paramount to your future success, but it’s really important to come to terms with the reality that not every paper can be a Cell, Science or Nature publication. Get those least publishable units (LPUs) out the door. It will show your R01 reviewers that you have a functional lab and are progressing towards those bigger papers. Plus, every publication counts towards your tenure package and the clock is running. In my experience, most manuscript preparations take longer than you think and time is not on your side.

Develop a thick hide: Science is hard, getting funding is hard, publishing is hard, teaching is hard and running a lab is hard. Get use to the fact that your grants and papers are going to get rejected, reviewers are going to hit you hard, and sometimes you’re going to get scooped. Take a breath, sleep on it and revisit with a fresh mind. Often times you will find that everything isn’t as bad as you first thought (of course some things take more time to get over). Don’t get discouraged - fight on! Besides, what’s the alternative?

Go to meetings: Don’t forget to attend and present at meetings (hopefully you’ve already started this as a postdoc). It’s critical that you interact and network with the vascular community. After all, they’re the ones reviewing your papers and grants. In this highly competitive environment, it’s beneficial to have a reviewer that can place your name and face to the work they are critiquing. This is also a good way to form collaborations. Plus, you may need recommendations and reviews from established investigators outside of your institute for your tenure package.

Get to know your administrators: I think people often overlook the importance of a good working relationship with their administrative staff. Get acquainted with your grants people and department administrators. Your grants are important and managing your research money is important – therefore I would suggest treating those people that help you manage the grant submissions and lab finances as important. I know it’s their job to assist you, but most people like to be treated as colleagues not as personal assistants. I’ve found that if you treat your administrative staff with respect, they will go out of their way to help you. Plus they will know some of the nuances of your institute and other tricks that will be unknown to you.

Balancing work and family: This particular balancing act can be very stressful and everyone’s situation is different. In my case, I try to make my time at work efficient so that I can squeeze in as much quality time at home without feeling guilty. Newsflash: you will still fell guilty. I think this is natural but I also think it means you recognize that your family is still important, which is a good thing. Try celebrating professional accomplishments, such as getting a grant, publishing your paper or grading your last exam, with your family. This is a good way to include them into your work life, and gives your children the opportunity to see that hard work is rewarded with fun.

Published March 8, 2018 - NAVBO NewsBEAT

Kazuyo Kegan, Johns Hopkins University


Lessons Learned
by Kazuyo Kegan, Johns Hopkins University

Kegan3 2My name is Kazuyo Kegan. I have been an Assistant Professor in the Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, since 2012. I recently received my first NIH R01 grant, which just started in December 2017. Our institution traditionally provides no direct salary support for non-clinical faculty. Thus, the transition from junior faculty to partial dependence on mentor-initiated funding, to a combination of mentor and independent support, to finally being fully independently funded has been extremely challenging. Before reaching this point, I had to obtain multiple small internal and external funding awards. I am still in the process of building a new lab, but I hope I can share a few ideas that might be helpful and important for writing grants and becoming an independent scientist.

It took a little while for me to understand the fundamental differences between writing a manuscript and writing a grant. When writing a manuscript, we try to describe things clearly, logically, and professionally. There is actually no room to express enthusiasm in it. On the contrary, I have learned that the key to writing a successful grant is to imbed your enthusiasm clearly into your writing. Besides making the science clear, you need to convince the reviewers that your grant is better and more novel, innovative, and feasible than any of the other applications. Here are several steps I have taken to obtain successful grants.

1. Start and plan early: In the first year after my promotion, I was advised that I should apply for an R01 grant at almost every cycle. I did try to do this during the first 2 years without success. Every 4 months, I would be at the bench for 2 months to move my research forward (I had no people to work on my project), generate preliminary data for the grant during the third month, and spend the fourth month writing and submitting a grant. With this schedule, I was not so productive in publication or in obtaining grants. Your productivity is one of the important factors the reviewers want to see for successful grants. I also learned that taking time to obtain strong preliminary data to support the overall hypothesis is the key to creating successful grants.

2. Assemble a support network: I like to finish things before the due date. I usually plan to finish my grant at least 2 weeks early. This tactic allows me to ask senior faculty members to read and evaluate the grant and our scientific editor to edit it. The comments from senior and experienced faculty members are helpful and provide the opportunity for brainstorming before submission. Nevertheless, it is important that you follow your heart and intuition when making final decisions regarding the direction of the grant if you receive multiple contrasting opinions. Also, create good relationships with the finance team and office of research administration, if your university has one. By working together to resolve issues and review the grant and budget, you will be pleasantly surprised by all that you learn about the policy behind grant management.

3. Writing is a skill not a genetic gift: It greatly helps me to allot time for writing, to schedule it into my day, and to set goals for each day and week. Keep track of your progress and reward yourself for meeting your goals. Make writing routine and mundane. I was given the suggestion to join a support writing network in which members encourage each other. As I did not have enough time to do so in person (I am a mother of 9-year-old twins), I created a support network on Social Networking Service (SNS) with scientists in academia from inside and outside of the US. When I feel alone writing grants during weekends and holidays, I can always find someone who is also working on a grant or paper, and we encourage each other. This resource has been a tremendous boost to my productivity and motivation.

4. Focus on creating Specific Aims and abstracts: I was told to dedicate a lot of time to writing, revising, and rewriting the Specific Aims page to make it perfect. A giant in our field also taught me to begin by drawing a picture. If you can draw a picture of what you want to do, then you are on the right path. In addition, the Specific Aims are critical for the peer review process because the majority of reviewers on the panel will likely read only the abstract and Specific Aims during the very short period given to judge and score the applications.

5. Resubmission: One of my biggest mistakes in the first years of working on grants was not communicating with program officer. I was too shy to pick up the phone and discuss how to revise the application. I was wrong. Many times they will help you to interpret the summary statement and offer strategic tips on how to be highly responsive to the reviewers' concerns. If you receive a “not fundable” review statement, please do not take it personally. It is easy for me to say this but very difficult to accomplish. It usually takes me at least a week to read the reviews without tears and all kinds of negative feelings. We should not stop there. Take a breath, calm down, and start reading the review with a cup of coffee (or a glass of wine works best for me!). I found that the critical review is one of the greatest aids to improving your science and application. If you think that the reviewers did not understand what you meant, you need to make more effort to convey your points clearly. If they misinterpreted your writing, then it is possible that many other people would misinterpret it same way.

What I wish I had known when I accepted my first position was that we must have so many new and different skills to transition from a junior faculty member to a successful independent investigator. I learned that we need to make decisions quickly and with conviction. Furthermore, dealing with negotiation—–we do it every day—requires disciplined communication skills, reliable persuasive strategies, the willingness to engage in conflict, and the ability to adapt to a rapidly changing environment.

Probably the most important message I have is to Be Resilient. Becoming an independent scientist in academia is hard. Science is a difficult field, no doubt. It takes years in the trenches to succeed. You may need to learn how to rise from the ashes several times in this path. Scientists who study stress and resilience say that it’s important to think of resilience as an emotional muscle that can be strengthened at any time. I always try to go back to the basics and reevaluate why I am doing this and what motivates me. I try to focus on what is fascinating and meaningful about what I do. What is important to me is the progress I am making in science and medicine, not what anybody is saying back. Then, the productivity naturally returns during difficult times. Do not hesitate to ask for help when necessary. We are more resilient when we have strong support networks to help us cope with a crisis. But we can get an even bigger resilience boost by giving support to others. By doing so, we create a positive feedback loop of helping others and being helped ourselves, This is an important way to enhance our own strength to create a life that we consider meaningful and purposeful.

Published April 5, 2018 - NAVBO NewsBEAT

Elisa Boscolo, Cincinnati Children’s Hospital


Lessons Learned
by Elisa Boscolo, Cincinnati Children’s Hospital

BoscoloIt’s time to fill the empty spaces ... in the laboratory and in your personal life!

… and all of a sudden … POOF! You jumped to the other side!

You have dreamed about it all of your life (or most of it), and you just cannot believe it has really happened. While you are pinching yourself to be sure it’s not a dream, your eyes open wide and what do you see? An empty office and an empty laboratory (Well, I wouldn’t even call it a laboratory as it’s just four walls and a stack of empty shelves!). Now you really miss your old lab mates and your previous mentor.

My name is Elisa Boscolo. I did my postdoctoral training at Boston Children’s Hospital and have been an Assistant Professor at the Cincinnati Children’s Hospital since 2014. Back then it surely was frustrating to start from scratch in a new institution and in a different city.

My first suggestion is to not rush in hiring personnel to staff your lab. Choose carefully and make sure they can stay in your lab for a few years, guaranteeing continuity after the initial period. For a faster take-off, start looking for personnel before your actual move; you can contact HR at your new institution and ask them to help opening positions for your lab. Set up Skype interviews and talk to the candidate multiple times to get to know them as much as you can. Make sure to call their previous mentors and ask a lot of questions – do not rely solely on formal letters of recommendations.

Managing people is challenging – little did I know about how hard this is, as I had a wonderful relationship with my former mentor. My advice is to make your expectations clear, write them down and use that list to make sure they are respected. Also, my mistake was to think that every post-doc has the same ambitions and passion for research that I do. Make sure to communicate with your team as much as you can to understand how facilitating their success can fulfill their own life goals and ambitions.

In this empty laboratory, you may suddenly feel lonely, as you will spend most of your time enclosed in your office writing grants, IACUC and IRB protocols, etc. My second advice is to make sure you connect with the other junior faculty at your institutions and try to set up regular meetings with them. Discuss grant opportunities, new data and mentoring issues. Help each other with grant writing and collaborations. And don’t forget that from time to time, you’ll want to have a friend to get a coffee together.

To ensure funding it is crucial to show productivity early on after you set up your lab. What I regret not doing is using the early slow times (slow production of data!) to think of a short-term project that could generate a manuscript in a two-year time frame, aimed at a decent impact factor journal, but not necessarily very high to avoid being trapped in endless cycles of resubmissions.

My last suggestion, as a woman scientist, is to not neglect your personal life because of the academic pressure. I somewhat put my personal life on hold until I became a junior faculty member and waited until then to start a family. Some days it’s just you and your beloved iMac, so when you finally close the office door, it’s a joy to know you will reunite with your family at home. I often wondered if it’s possible to have a career and children. Now that I have a young daughter, I feel more productive during my time at work. When I feel frustrated after a grant or manuscript rejection, instead of healing my suffering with Italian wine, my daughter smiles, makes me forget these disappointments, and re-charges my mind for the next challenge.

Always do your best work and learn to be patient; there will be times when productivity is slower than you wish. Make the best out of this time! In few years you will see that your lab has no empty spaces left and has already produced phenomenal data – hopefully you have already published some of them!

Published May 3, 2018 - NAVBO NewsBEAT

John C. Chappell, Virginia Tech Carilion Research Institute


Lessons Learned
by John Chappell, Virginia Tech Carilion Research Institute

CHAPPELL PhotoMaintain a work-life balance— Many careers can consume you, and a career in academic science can certainly tip the work-life balance towards working almost continuously. What started out as a passion and a curiosity to discover new things about the vascular system can quickly turn into seemingly endless grant writing, manuscript preparation, e-mail replies, and so on. I would urge new independent investigators to work hard on their science, but to also find the aspects of life that provide rest and reinvigoration outside of their science and the workplace. Striving for and maintaining that work-life balance seems to be a critical skill to help avoid burnout and sustain you through the highs and lows of grant/paper reviews and all of the other challenges you will face.

Find your place of Zen— In reading the Lessons Learned contributions from my colleagues, one theme emerges very clearly—this career path is full of many difficult challenges. Publishing, funding, managing a lab, etc. In the midst of the ups and downs, I have found that staying connected to the science and keeping my hands on the experiments has been incredibly helpful. My place of Zen is at my confocal, taking high-resolution images of biological phenomena – it has been my shelter during the storms of never-ending demands. Find the part of science that fueled your love of what you do, and fight to keep that as part of your schedule. I try to use my confocal at least once every week or two. It helps clear my mind and reinvigorates me, while also inspiring new ideas and avenues for research. I encourage you to find that quiet place of enlightenment, free from worrying about what you cannot change.
Be focused but stay curious— When I started down the path of a career in academic science, one aspect I enjoyed the most was that curiosity was encouraged. As many of my colleagues have cautioned me, staying focused is important for building a critical mass of productivity in a particular area. But I would encourage a balance. Write down your curiosities. One day you may have the personnel and funding to pursue an idea you initially thought was a tangent, but it could develop into an unexpected discovery.
Aim for clarity— Have someone outside your area of focus read your grants and papers. They will help you distill your writing down to the basic principles that must be understood by reviewers. If they can’t understand the basic concepts in the grant or manuscript, the review will not go well. I tend to overcomplicate many things in life, and this is especially true for my writing. Reviewer expertise is unlikely to coincide perfectly with your area of research, and even if it does, you will make them happier (and more likely to review favorably) if they can understand what you are describing on a very basic level. Schematics help.
Seek out mentoring— I was not connected to a formal mentor when I started my position, and I was initially reluctant to intrude into the busy schedules of my colleagues with my many questions about how to approach grant writing, setting up my lab, or anything really. I agree with a number of the other Lessons Learned authors that you have to find your own path for many decisions that must be made. Mentors can be incredibly helpful, though, in sharing things that worked or didn’t work for them, or as sounding boards for ideas that are still developing. You can glean from others specific ideas that you might want to weave together and integrate into your own approach to leading your lab, seeking funding, and doing your best science.
Don’t be afraid to be provocative— This item is fairly specific to grant writing, and I thought this insight into grant review was particularly helpful. A colleague of mine is currently serving on study section. I asked him to read one of my R01 grant proposals as he would as a study section reviewer. He graciously accepted and, when giving me his feedback, he said, “It’s a good grant, and will potentially (imagine air quotations) “fill a gap in knowledge”, but so will most of the other grants in my pile. As a reviewer with 10-12 grants in my pile, you need to wake me up. Provoke me. The worst-case scenario is that your grant lands in the bottom of my rankings, but honestly it’s no worse than being too conservative and landing in the middle. Neither the middle nor the bottom grants are funded, so why not aim for the top? Don’t give me clichés. Give me specifics and a thought-provoking question. Get my attention.” Certainly one person’s opinion, but I thought it was a helpful glimpse into the grant review process.

Published October 22, 2018 - NAVBO NewsBEAT