Jeffrey S. Isenberg, M.D., M.P.H.
December 1, 2012
Division of Pulmonary, Allergy and Critical Care Medicine
Department of Medicine and the Vascular Medicine Institute of the University of Pittsburgh School of Medicine
| Jeff Isenberg, M.D. MPH | Principal Investigator |
| Enrico M. Novelli, MD | Assistant Professor |
| Natasha M. Rogers, MD, PhD | Post Doctoral fellow |
| Maryam Sharifi-Sanjani, PhD | Post Doctoral fellow |
| Heather E. Knupp, MS | Research specialist |
| Lisa R. Negly | Undergraduate |
| Daniel P. Dempe | Undergraduate |
| Johannes Kutten | MD-PhD student |
Primary Research:
Our lab focuses on ligand receptor interactions that promote cellular and tissue injury. We are presently investigating a widely expressed cell receptor CD47, and its high affinity ligand thrombospondin-1 and the role this pathway plays in several diseases including pulmonary arterial hypertension, sickle cell disease, systemic arterial vasculopathy, heart failure and acute kidney injury. .
Visit the lab's web site:Â http://www.vmi.pitt.edu/isenberglab.html
Recent Publications:
Thrombospondin-1 Regulates Blood Flow via CD47 Receptor-Mediated Activation of NADPH Oxidase 1. Csányi G, Yao M, RodrÃguez AI, Ghouleh IA, Sharifi-Sanjani M, Frazziano G, Huang X, Kelley EE, Isenberg JS, Pagano PJ. Arterioscler Thromb Vasc Biol. 2012 Dec;32(12):2966-73. doi: 10.1161/ATVBAHA.112.300031. Epub 2012 Oct 18. PMID:23087362
Activation of parenchymal CD47 promotes renal ischemia-reperfusion injury. Rogers NM, Thomson AW, Isenberg JS. J Am Soc Nephrol. 2012 Sep;23(9):1538-50. doi: 10.1681/ASN.2012020137. Epub 2012 Aug 2. PMID: 22859854
Plasma thrombospondin-1 is increased during acute sickle cell vaso-occlusive events and associated with acute chest syndrome, hydroxyurea therapy, and lower hemolytic rates. Novelli EM, Kato GJ, Ragni MV, Zhang Y, Hildesheim ME, Nouraie M, Barge S, Meyer MP, Hassett AC, Gordeuk VR, Gladwin MT, Isenberg JS. Am J Hematol. 2012 Mar;87(3):326-30. doi: 10.1002/ajh.22274. Epub 2012 Feb 8. PMID:22318901
Activated CD47 promotes pulmonary arterial hypertension through targeting caveolin-1. Bauer PM, Bauer EM, Rogers NM, Yao M, Feijoo-Cuaresma M, Pilewski JM, Champion HC, Zuckerbraun BS, Calzada MJ, Isenberg JS. Cardiovasc Res. 2012 Mar 15;93(4):682-93. Epub 2012 Jan 2. PMID:22215724
The matricellular protein thrombospondin-1 globally regulates cardiovascular function and responses to stress via CD47. Roberts DD, Miller TW, Rogers NM, Yao M, Isenberg JS. Matrix Biol. 2012 Apr;31(3):162-9. Epub 2012 Jan 14. Review. PMID:22266027
Activated CD47 regulates multiple vascular and stress responses: implications for acute kidney injury and its management. Rogers NM, Yao M, Novelli EM, Thomson AW, Roberts DD, Isenberg JS. Am J Physiol Renal Physiol. 2012 Oct;303(8):F1117-25. doi: 10.1152/ajprenal.00359.2012. Epub 2012 Aug 8. PMID:22874763