Manfred Boehm, M.D.

Laboratory of Cardiovascular Regenerative Medicine, Center for Molecular Medicine
National Heart, Lung, and Blood Institute
National Institutes of Health
Bethesda, MD

Front Row (l to r): Cynthia St. Hilaire, Guibin Chen,Zhen Yu,Dan Yang,Fang Fang,Robin Schwartzbeck
Back Row (l to r): Avram Walts, Jan Lanzer, Jean-Michel Davaine, Alejandra Negro, Manfred Boehm

Primary Research:

Dr. Boehm's primary research interests are in vascular biology and the genetics of vascular remodeling in human diseases. His laboratory generates animal models and patient-specific disease models, including induced pluripotent stem cell-based systems, to understand the cellular and molecular mechanisms of vascular remodeling in rare or unknown inherited and acquired vascular diseases. A primary focus is on inherited forms of pathological remodeling observed during vascular calcification, vascular inflammation and vascular proliferative disease. The elucidation of the cellular contributions and pathways involved in vascular remodeling will be critical for understanding disease mechanism and for the development of potential therapeutic applications.

Find more information on the web:
http://www.nhlbi.nih.gov/research/intramural/researchers/pi/boehm-manfred/index.html

Lab Members:

Guibin Chen, MD/PhD – Staff Scientist
Jean-Michel Davaine, MD – Clinical Fellow
Fang Fang, MD/PhD – Postdoctoral Fellow
Hui Jin – Graduate Student
Jan Lanzer – Medical Student
Alejandra Negro, PhD – Research Fellow
Robin Schwartzbeck – Animal Research Assistant
Cynthia St. Hilaire, PhD – Research Fellow
Avram Walts, MS – Biologist & Laboratory Manager
Dan Yang, MD/PhD – Staff Scientist
Zhen Yu – Graduate Student

Recent Publications:

TGF-β signaling mediates endothelial-to-mesenchymal transition (EndMT) during vein graft remodeling. Cooley BC, Nevado J, Mellad J, Yang D, St Hilaire C, Negro A, Fang F, Chen G, San H, Walts AD, Schwartzbeck RL, Taylor B, Lanzer JD, Wragg A, Elagha A, Beltran LE, Berry C, Feil R, Virmani R, Ladich E, Kovacic JC, Boehm M. Sci Transl Med. 2014 Mar 12;6(227):227ra34

Early-onset stroke and vasculopathy associated with mutations in ADA2. Zhou Q, Yang D, Ombrello AK, Zavialov AV, Toro C, Zavialov AV, Stone DL, Chae JJ, Rosenzweig SD, Bishop K, Barron KS, Kuehn HS, Hoffmann P, Negro A, Tsai WL, Cowen EW, Pei W, Milner JD, Silvin C, Heller T, Chin DT, Patronas NJ, Barber JS, Lee CC, Wood GM, Ling A, Kelly SJ, Kleiner DE, Mullikin JC, Ganson NJ, Kong HH, Hambleton S, Candotti F, Quezado MM, Calvo KR, Alao H, Barham BK, Jones A, Meschia JF, Worrall BB, Kasner SE, Rich SS, Goldbach-Mansky R, Abinun M, Chalom E, Gotte AC, Punaro M, Pascual V, Verbsky JW, Torgerson TR, Singer NG, Gershon TR, Ozen S, Karadag O, Fleisher TA, Remmers EF, Burgess SM, Moir SL, Gadina M, Sood R, Hershfield MS, Boehm M, Kastner DL, Aksentijevich I. N Engl J Med. 2014 Mar 6;370(10):911-20.

NT5E mutations and arterial calcifications. St Hilaire C, Ziegler SG, Markello TC, Brusco A, Groden C, Gill F, Carlson-Donohoe H, Lederman RJ, Chen MY, Yang D, Siegenthaler MP, Arduino C, Mancini C, Freudenthal B, Stanescu HC, Zdebik AA, Chaganti RK, Nussbaum RL, Kleta R, Gahl WA, Boehm M. N Engl J Med. 2011 Feb 3;364(5):432-42.

Stat3-dependent acute Rantes production in vascular smooth muscle cells modulates inflammation following arterial injury in mice. Kovacic JC, Gupta R, Lee AC, Ma M, Fang F, Tolbert CN, Walts AD, Beltran LE, San H, Chen G, St Hilaire C, Boehm M. J Clin Invest. 2010 Jan;120(1):303-14.

Ma M., Ding S., Lundqvist A., San H., Fang F., Konoplyannikov M., Berry C., Beltran L., Chen G., Kovacic J.C. Boehm M. Major Histocompatibility Complex-I Expression on Embryonic Stem Cell-Derived Vascular Progenitor Cells Is Critical for Syngeneic Transplant Survival, Stem Cells 2010, 28(9), 1465-1475

Olive M., Mellad J.A., Beltran L.E., Ma, M., Cimato T., Noguchi A.C., Hong San H., Childs R., Kovacic J.C., Boehm M. p21Cip1 modulates arterial wound repair through the SDF-1/CXCR4 axis. J Clin Invest 2008, 118: 2050-2061.