Elisabetta Dejana, Ph.D.
May 1, 2016
FIRC Institute of Molecular Oncology, Milan Italy
Immunology, Genetics and Pathology, Rudbeck Laboratory
Uppsala University, Uppsala Sweden
Primary Research:
The structure and function of endothelial cell-to-cell junctions: their role in controlling vascular permeability and morphogenesis.
Recent Publication:
- Bravi L, Malinverno M, Pisati F, Rudini N, Cuttano R, Pallini R, Martini M, Larocca LM, Locatelli M, Levi V, Bertani GA, Dejana E, Lampugnani MG. Endothelial Cells Lining Sporadic Cerebral Cavernous Malformation Cavernomas Undergo Endothelial-to-Mesenchymal Transition. Stroke. 2016 Mar;47(3):886-90.
- Dejana E, Betsholtz C.NEURODEVELOPMENT. Oligodendrocytes follow blood vessel trails in the brain.Science. 2016 Jan 22;351(6271):341-2.
- Giampietro C, Disanza A, Bravi L, Barrios-Rodiles M, Corada M, Frittoli E, Savorani C, Lampugnani MG, Boggetti B, Niessen C, Wrana JL, Scita G, Dejana E. The actin-binding protein EPS8 binds VE-cadherin and modulates YAP localization and signaling. J Cell Biol. 2015 Dec 21;211(6):1177-92.
- Cuttano R, Rudini N, Bravi L, Corada M, Giampietro C, Papa E, Morini MF, Maddaluno L, Baeyens N, Adams RH, Jain MK, Owens GK, Schwartz M, Lampugnani MG, Dejana E. KLF4 is a key determinant in the development and progression of cerebral cavernous malformations. EMBO Mol Med. 2015 Nov 26;8(1):6-24.
- Spadoni I, Zagato E, Bertocchi A, Paolinelli R, Hot E, Di Sabatino A, Caprioli F, Bottiglieri L, Oldani A, Viale G, Penna G, Dejana E, Rescigno M. A gut-vascular barrier controls the systemic dissemination of bacteria. Science. 2015 Nov 13;350(6262):830-4.
- Giampietro C, Deflorian G, Gallo S, Di Matteo A, Pradella D, Bonomi S, Belloni E, Nyqvist D, Quaranta V, Confalonieri S, Bertalot G, Orsenigo F, Pisati F, Ferrero E, Biamonti G, Fredrickx E, Taveggia C, Wyatt CD, Irimia M, Di Fiore PP, Blencowe BJ, Dejana E, Ghigna C. The alternative splicing factor Nova2 regulates vascular development and lumen formation. Nat Commun. 2015 Oct 8;6:8479.
- Marchi S, Corricelli M, Trapani E, Bravi L, Pittaro A, Delle Monache S, Ferroni L, Patergnani S, Missiroli S, Goitre L, Trabalzini L, Rimessi A, Giorgi C, Zavan B, Cassoni P, Dejana E, Retta SF, Pinton P. Defective autophagy is a key feature of cerebral cavernous malformations. EMBO Mol Med. 2015 Sep 28;7(11):1403-17.
- Bravi L, Rudini N, Cuttano R, Giampietro C, Maddaluno L, Ferrarini L, Adams RH, Corada M, Boulday G, Tournier-Lasserve E, Dejana E, Lampugnani MG. Sulindac metabolites decrease cerebrovascular malformations in CCM3-knockout mice. Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8421-6.
- Corada M, Morini MF, Dejana E. Signaling pathways in the specification of arteries and veins. Arterioscler Thromb Vasc Biol. 2014 Nov;34(11):2372-7.
- Corada M, Orsenigo F, Morini MF, Pitulescu ME, Bhat G, Nyqvist D, Breviario F, Conti V, Briot A, Iruela-Arispe ML, Adams RH, Dejana E. Sox17 is indispensable for acquisition and maintenance of arterial identity. Nat Commun. 2013;4:2609.
Lab URLs:
http://www.ifom.eu/en/cancer-research/research-labs/research-lab-dejana.php ( Milan)
http://www.igp.uu.se/research/vascular-biology/elisabetta-dejana (Uppsala)
Lab Members:
| Staff Scientists - Ferruccio Breviario Monica Corada Maria Grazia Lampugnani Fabrizio Orsenigo Claudio MadernaPhD Students - Ganesh Bath Surya Batta Cecilia SavoraniGraduate Students - Linda Terreran Nikolaos Kakogiannos | Post Docs - Roberto Cuttano Costanza Giampietro Monica Giannotta Matteo Malinverno Noemi Rudini Abdalla Abu Taha Sara Cunha Joppe Oldenburg Veronica Sundell |
Collaborative Relationships:
Lena Claesson-Welsh (Uppsala University, Uppsala, Sweden)
Christer Betsholtz (Uppsala University, Uppsala, Sweden)
Kari Alitalo ( Biomedicum, Helsinki, Finland)
Peter Carmeliet (VIB Vesalius Research Center, leuven, Belgium)
Michael Simons (Yale University, New Haven, CT)
Martin Schwartz (Yale University, New Haven, CT)
Laboratory Motto:
