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Members’ Labs

Guizhen Zhao, PhD

Assistant Professor
Department of Pharmacological and Pharmaceutical Sciences
University of Houston

Primary Research:

The Zhao lab is dedicated to uncovering the epigenetic and molecular mechanisms underlying cardiovascular diseases (CVD), including aortic aneurysm and dissection, and atherosclerosis, while also driving innovations in drug discovery. Currently, our research focuses on elucidating the metabolic and epigenetic (metaboloepigenetic) properties of vascular cells in vascular remodeling and CVD development. We extensively utilize animal models and employ a range of genetic and epigenetic techniques, such as bulk RNA-seq, single-cell RNA-seq, chromatin accessibility profiling (ChIP-seq and ATAC-seq), spatial transcriptomics, and metabolomics.

Laboratory web site URL:

https://www.uh.edu/pharmacy/directory-home/pps-faculty/guizhen-zhao/

Recent Presentations:

1. Endothelial KLF11 is a novel endogenous protectant against diabetic atherosclerosis. 2023 AHA scientific Sessions, Philadelphia.
2. 5. BAF60c in Cardiovascular Development and Diseases. Integrative Aspects of Diabetes, Obesity and Metabolism Research Club by Michigan Diabetes Research Center, The Michigan Nutrition Obesity Research Center, The Department of Molecular and Integrative Physiology, University of Michigan. 03/2023
3. Endothelial Cell Heterogeneity in Diabetic Atherosclerosis. Single Cell Genomics in Obesity and Diabetes (scGOD) Research Club by Michigan Diabetes Research Center and Life Sciences Institute, University of Michigan. 01/2022.
4. BAF60c Prevents Abdominal Aortic Aneurysm Formation through Maintaining Vascular Smooth Muscle Cell Homeostasis. AHA Vascular Discovery: From Genes to Medicine 2021.

 

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Daniela Simona Ardelean, M.D., Ph.D.

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A. Wayne Orr, Ph.D.

July 1, 2016

Associate Professor, Department of Pathology and Translational Pathobiology and the…

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R. Sathish Srinivasan, Ph.D.

June 1, 2016

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Elisabetta Dejana, Ph.D.

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FIRC Institute of Molecular Oncology, Milan Italy Immunology, Genetics and…

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