Skip to content

Home  |  JOIN  |  Contact Us  |  Member Portal

Members’ Labs

Ke Yuan, PhD

Assistant Professor
Department of Pediatrics
Division of Pulmonary Medicine
Boston Children's Hospital

Primary Research:

The Ke Yuan Lab is dedicated to uncovering the cellular and molecular mechanisms that drive vascular remodeling in pulmonary arterial hypertension (PAH). Our research primarily focuses on defining the distinct roles of vascular cell populations, particularly pericytes, endothelial cells, and smooth muscle cells, in the initiation and progression of PAH. The ultimate goal is to identify therapeutic targets capable of reversing pathological remodeling and restoring normal vascular function. In our recent work, we identified Higd1b as a pericyte-specific gene marker and developed a novel Higd1b-CreERT2 knock-in mouse model. This genetic tool provides a unique opportunity to dissect the multifaceted roles of pericytes in vascular development, homeostasis, and injury response.

Laboratory web site URL:

https://www.yuankelab.com

Laboratory Motto:

Thinking beyond boundaries.

Previously Featured Labs

Mary Wallingford, Ph.D.

July 1, 2021

Mother Infant Research Institute, Tufts Medical Center Molecular Cardiology Research…

Learn More
Group standing outside a building

Isabella Grumbach, M.D., Ph.D., FAHA

June 1, 2021
Learn More

Carmen Halabi, M.D., Ph.D.

May 1, 2021

Department of Pediatrics Division of Nephrology Washington University School of…

Learn More

Rio Sugimura, M.D., Ph.D.

April 1, 2021

School of Biomedical Sciences Li Ka Shing Faculty of Medicine…

Learn More

Yi Fan, M.D., Ph.D.

March 1, 2021

Department of Radiation Oncology, Cardiovascular Institute and Abramson Cancer Center…

Learn More
Clint Miller Lab

Clint Miller, Ph.D.

February 1, 2021

Center for Public Health Genomics University of Virginia Charlottesville, VA…

Learn More